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Alpha Lipoic Acid / Acetyl L-Carnitine

Two Energy Powerhouses in One High-Potency Formula

Alpha lipoic acid and acetyl L-carnitine are two "powerhouses" for energy production.

ALA / ALCAlpha Lipoic acid improves mitochondrial function (the "energy producing units" of the cell) is also involved in the conversion of carbohydrates to energy. It is used for:

  • overweight and obesity
  • brain health
  • neurological disease
  • cataract prevention
  • diabetes
  • heart disease
  • detoxification support

Acetyl-L-Carnitine (ALC), a derivative of the amino acid L-carnitine, is a vitamin-like compound that transports fatty acids ("fuel") into cells.  It has been approved in Europe as a "drug" to treat heart and neurological disease. It also acts as a powerful antioxidant in the brain.  The acetyl form of L-carnitine (ALC) was found to be substantially more active than L-carnitine in brain cells.

Together, these two nutrients pack a powerful punch.

For example, the combination of ALA and ALC was found, when fed to old rats, to significantly improve metabolic function while decreasing oxidative stress and improving cognition (thought function) suggesting it's value in an Anti Aging program. According to the researchers:

"Supplementing the diet of old rats with ALCAR+LA [ALA / ALC] significantly improves many of the most frequently encountered age-related changes in mammals — namely loss of energy metabolism, increased oxidative stress, decreased physical activity, and [...] impaired cognitive function." (48)

The combination also proved valuable in patients with coronary artery disease and hypertension, and metabolic syndrome:

" Alpha-lipoic acid and acetyl-L-carnitine reduce oxidative stress and improve mitochondrial function. [...] we examined the effects of combined alpha-lipoic acid /acetyl-L-carnitine treatment and placebo (eight weeks per treatment) on vasodilator function and blood pressure in 36 subjects with coronary artery disease. Active treatment increased brachial artery diameter by 2.3%, consistent with reduced arterial tone. Active treatment tended to decrease systolic blood pressure for the whole group and had a significantly effect in the subgroup with blood pressure above the median and in the subgroup with the metabolic syndrome..." (57)

In addition to individual formulas of ALA and ALC, we now offer a high-potency supplement which combines both nutrients in a single formula.

One bottle of ALA-ALC is equivalent to two bottles each of our separate ALA and ALC formulas. For those who need to take both nutrients in higher potencies, this represents a savings of over $30.

Supplemental Facts

Serving Size: 1 Capsule(s)
Acetyl L-Carnitine 525 mg
Alpha Lipoic Acid 225 mg 

Other Ingredients: Gelatin, magnesium stearate, and stearic acid.

Recommended Dose: One or two caps daily or as directed by your healthcare professional.

ALA-ALC 60 capsules $27.97

Enter Quantity Desired and Click "Add To Cart" Button

References:

  1. Noland RC, Koves TR, Seiler SE, Lum H, Lust RM, Ilkayeva O, Stevens RD, Hegardt FG, Muoio DM. Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J Biol Chem. 2009 Aug 21;284(34):22840-52. Epub 2009 Jun 24.
  2. Pescosolido N, Imperatrice B, Karavitis P. Ocular disorders secondary to systemic disease and the potential role of carnitines. Drugs R D. 2008;9 Suppl 1:15-22. doi: 10.2165/0126839-200809001-00003.
  3. Power RA, Hulver MW, Zhang JY, Dubois J, Marchand RM, Ilkayeva O, Muoio DM, Mynatt RL.Carnitine revisited: potential use as adjunctive treatment in diabetes. Diabetologia. 2007 Apr;50(4):824-32. Epub 2007 Feb 20.
  4. Siliprandi N, Siliprandi D, Ciman M. Stimulation of oxidation of mitochondrial fatty acids and of acetate by acetylcarnitine. Biochem J. 1965 Sep;96(3):777-80.
  5. Stephens FB, Constantin-Teodosiu D, Greenhaff PL. New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. J Physiol. 2007 Jun 1;581(Pt 2):431-44. Epub 2007 Mar 1.
  6. Calvani M, Reda E, Arrigoni-Martelli E. Regulation by carnitine of myocardial fatty acid and carbohydrate metabolism under normal and pathological conditions. Basic Res Cardiol. 2000 Apr;95(2):75-83.
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  8. Iliceto S, Scrutinio D, Bruzzi P, D'Ambrosio G, Boni L, Di Biase M, Biasco G, Hugenholtz PG, Rizzon P. Effects of L-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the L-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) Trial.J Am Coll Cardiol. 1995 Aug;26(2):380-7.
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  15. Liu J.The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview. Neurochem Res. 2008 Jan;33(1):194-203. Epub 2007 Jun 29
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  23. Pisano C, Pratesi G, Laccabue D, Zunino F, Lo Giudice P, Bellucci A, Pacifici L, Camerini B, Vesci L, Castorina M, Cicuzza S, Tredici G, Marmiroli P, Nicolini G, Galbiati S, Calvani M, Carminati P, Cavaletti G. Paclitaxel and Cisplatin-induced neurotoxicity: a protective role of acetyl-L-carnitine. Clin Cancer Res. 2003 Nov 15;9(15):5756-67.
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  30. Liu J, Killilea DW, Ames BN. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid.Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1876-81.
  31. Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med 1997;22(1-2):359-78.
  32. Ruhnau KJ, Meissner HP, Finn JR, et al. Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy. Diabet Med 1999;16:1040–3.
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  36. Morcos M, Borcea V, Isermann B, et al. Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study. Diabetes Res Clin Pract 2001;52:175–83.
  37. Konrad T, Vicini P, Kusterer K, et al. alpha lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care 1999;22:280–7.
  38. Ruhnau KJ, Meissner HP, Finn JR, et al. Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy. Diabet Med 1999;16:1040–3.
  39. Ruhnau KJ, Meissner HP, Finn JR, et al. Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy. Diabet Med 1999;16:1040–3.
  40. Reljanovic M, Reichel G, Rett K, et al. Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy. Free Radic Res 1999;31:171–9.
  41. Ziegler D, Schatz H, Conrad F, et al. Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized controlled multicenter trial (DEKAN Study). Diabetes Care 1997;20:369–73.
  42. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radic Biol Med 1999;27:309–14.
  43. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy. Diabetes Care 1999;22:1296–301.
  44. Ziegler D, Ametov A, Barinov A, et al. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care 2006;29:2365–70.
  45. Morcos M, Borcea V, Isermann B, et al. Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study. Diabetes Res Clin Pract 2001;52:175–83.
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    47.) Liu J, Atamna H, Kuratsune H, Ames BN. Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann N Y Acad Sci 2002 Apr;959:133-66.
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  48. Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc Natl Acad Sci USA 2002 Feb 19;99(4):1870-5
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