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Antimicrobial for the GI Tract

GoldensealGoldenseal (Hydrastis canadensis) root has potent antimicrobial properties. Because the active ingredient appears to be an alkaloid, most of these anti-microbial properties remain confined to the GI tract.

Goldenseal has been found to be an effective antimicrobial against:

  • Chlamydia
  • E. coli
  • Salmonella typhi
  • Entamoeba histolytica
  • Staphylococcus aureus
  • Streptococcus sanguis
  • Pseudomonas aeruginosa
  • Helicobacter pylori
  • other Gram-positive bacteria and fungi

Some studies suggest that goldenseal may also be effective against viruses, fungi, protozoans and helminths (worms).

Look for goldenseal products with standardized berberine/hydrastine (alkaloid) content as these will have the highest potency.

Because goldenseal is becoming a threatened species, some conscientious formulas contain Goldthread (coptis chinensis) in addition to goldenseal to supplement the berberine content of the formula.

Goldenseal is a special order product - please call.

Please read more about the benefits of Berberine here.


1.) Hahn FE, Ciak J. Berberine. Antibiotics 1976;3:577–88.
2.) Kim SH, Lee SJ, Lee JH, Sun WS, Kim JH. Antimicrobial activity of 9-O-acyl- and 9-O-alkylberberrubine derivatives. Planta Med. 2002 Mar;68(3):277-81.
3.) Scazzocchio F, Cometa MF, Tomassini L, Palmery M. Antibacterial activity of Hydrastis canadensis extract and its major isolated alkaloids. Planta Med. 2001 Aug;67(6):561-4.
4.) Mahady GB, Pendland SL, Stoia A, Chadwick LR. In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis.Phytother Res. 2003 Mar;17(3):217-21.
5.) [no authors listed]. Berberine. Altern Med Rev. 2000 Apr;5(2):175-7.


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Cover of Wellness Club Holistic Health Handbook

This 140 page health manual covers 70 diseases and alternative medicine treatment options, including the latest scientific information on vitamins, herbs, diet, nutrition and exercise. Also included are descriptions of many of the products available in our alternative medicines pharmacy.

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