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Maxi Flavone™

Maxi FlavoneBroad-Spectrum Herbal Formula
(Anti-inflammatory, Antioxidant and TNF-inhibiting)

Radical Oxygen Species (ROS), elevated TNF-alpha and inflammation are known to play a significant role in many cases of infertility in both men and women.

Radical Oxygen Species (ROS) and Infertility

Radical Oxygen Species (ROS, also called "free radicals") include the hydroxyl radical, hydrogen peroxide, lipid peroxide, hypochlorite, chloramines, superoxide anion, peroxyl radical to name just a few. Inflammation is a primary cause of increased ROS.

In women, Radical Oxygen Species are detrimental to both natural and assisted fertility.1-8 ROS is also associated with polycystic ovarian disease, endometriosis, spontaneous abortions, preeclampsia, hydatidiform mole, embryopathies, preterm labor, and intrauterine growth retardation.2-3

In men, Radical Oxygen Species have been shown to decrease sperm motility and concentration and is associated with male infertility of unknown cause.9-32 ROS in males also damages DNA and should therefore be corrected even when assisted pregnancy is planned.31,36,40 The effect of ROS on male fertility is so well-established that many fertility specialists consider routinely testing for ROS in sub-fertile men.

Tumor Necrosis Factor-alpha (TNF-α) and Infertility

Tumor Necrosis Factor-alpha (TNF-a) is an inflammatory cytokine that stimulates free radical production by mitochondria. Don't let the term "tumor" alarm you; everyone has TNF-α in their body. Excessive amounts of TNF-α impair fertility.

In women, high TNF-α suppresses ovarian function, increases Natural Killer cells (NK cells) and is associated with infertility. High TNF-α is also associated with recurrent spontaneous abortion.

In men, high TNF-α is associated with decreased sperm count and motility.20

Maxi Flavone™

Broad-Spectrum Herbal Formula

Maxi Flavone is a broad-spectrum herbal antioxidant formula that affords protection from multiple ROS species, lowers TNF-alpha and is anti-inflammatory. Flavonoid-containing herbs have a synergistic effect when used in combination.41,71

Maxi Flavone supplies therapeutic doses of the most well-studied flavonoid herbs including:

I.) Pycnogenol (Pinus maritima) antioxidant and antiinflammatory effects. Please see the extensive reference list elsewhere on this website:
Grape Seed Extract and Pycnogenol

II.) Red Grape Seed (Vitus vinifera) with seeds, skin and stems which therefore contains Resveretrol. Both have potent antioxidant and anti-inflammatory effects. Please see the extensive reference list on my website: grapeseed.htm . Resveretrol also suppresses TNF-α.72 Please see the extensive reference list elsewhere on this website: Grape Seed Extract

III.) Bilberry (Vaccinium myrtillus), the most potent of the edible berries (39), has significant antioxidant and anti-inflammatory properties 41-43,73-7. Bilberry inhibits TNF-α43 , lipid peroxidation73-74 and is an active radical scavenger of H2O242,76, superoxide and peroxynitrite.41

IV.) Green Tea (Camillia sinesis) is an antioxidant that suppresses TNF-α.44-48 It has been shown to cause regression of endometriosis in animal models.49-50

V.) Ginkgo (Ginkgo biloba) is an antioxidant that has TNF-α suppressing properties.51-57 Ginkgo raises the radical-scavenging enzymes glutathione, SOD and catalase.51-52 It has also been shown to relieve symptoms of congestive PMS.56

VI.) Milk Thistle (Silybum marianum) is an antioxidant and antiinflammatory59-63 that significantly inhibits TNF-α. 58-61,63
It has been shown to modulate immune response in vivo.60

VII.) Citrus Bioflavonoids (with hesperidin, narginen and other flavonoids) have antioxidant64-67,69, antiinflammatory58,60,64,66, and TNF-a inhibiting properties.64

Why Dr. Myatt Recommends Maxi Flavone™

Maxi Flavone is a state-of-the-art formulation of flavonoid-containing herbs with synergistic effects specific to fertility enhancement. Only full-spectrum extracts, not isolated flavonoids are included, thus preserving the synergistic activity of all naturally-occurring phytonutrient compounds.

Maxi Flavone contains optimal doses of the flavonoid herbs which quench Radical Oxygen Species (ROS), lower TNF-α and NK cell activity (only when excessive) and decrease excess inflammation.

In addition to the beneficial effect on fertility, these herbs also have numerous beneficial effects on overall health. Maxi Flavone™ is a potent formula providing support for immune function, circulatory health, liver detoxification mechanisms, and antioxidant pathways.

Suggested Dose for Fertility:
Women: 1 capsule per day with a meal.
Men: 1 capsule, 2 times per day with meals.

NOTE: Two capsules of Maxi Flavone™ is equivalent to 10 to 12 tablets or capsules of individual extracts taken separately, resulting in significant cost savings.

Due to strong interest in this formula we may occasionally become backordered, with shipping delayed by up to a week.

Because of this we recommend that our Maxi Flavone customers consider ordering two bottles, re-order when they have completed the first bottle and never worry about running out of this important flavonoid / antioxidant / TNF-inhibiting formula.

For our fertility patients and customers, Dr. Myatt recommends that this formula be continued through conception and for the duration of pregnancy.

Product # N308 (60 Caps) $46.95

Enter Quantity Desired and Click "Add To Cart" Button

Supplement Facts
Serving Size 1 Capsule (60 Caps per bottle)

Amount Per Capsule % Daily Value


Pycnogenol®** Pine Bark (Pinus maritima) dried extract 5 mg *

Red Grape (Vitis vinifera) seeds, skin, and stems, dried extract with resveratrol 100 mg *

Bilberry (Vaccinum myrtillus) fruit, dried extract, min. 25% anthocyanosides 60 mg *

Green Tea (Camellia sinensis) leaf, dried extract, min. 50% catechins (polyphenols) 180 mg *

Ginkgo (Ginkgo Biloba) leaf, dried extract, min. 24% ginkgo flavone glycosides and 6% terpene lactones 40 mg *

Milk Thistle (Silybum marianum) fruit, dried extract, min. 80% silymarin 100 mg *

Citrus Bioflavonoid Complex, min. 50% bioflavonoids 125 mg *



* Daily value not established

 

References

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2.) Agarwal A, Gupta S, Sekhon L, Shah R. Redox considerations in female reproductive function and assisted reproduction: from molecular mechanisms to health implications. Antioxid Redox Signal.2008 Aug;10(8):1375-403.
3.) Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol. 2005 Jul 14;3:28.
4.) Agarwal A, Gupta S, Sharma R. Oxidative stress and its implications in female infertility - a clinician's perspective. Reprod Biomed Online. 2005 Nov;11(5):641-50.
5.) Agarwal A, Gupta S, Sikka S. The role of free radicals and antioxidants in reproduction. Curr Opin Obstet Gynecol. 2006 Jun;18(3):325-32.
6.) Agarwal A, Said TM, Bedaiwy MA, Banerjee J, Alvarez JG. Oxidative stress in an assisted reproductive techniques setting. Fertil Steril. 2006 Sep;86(3):503-12. Epub 2006 Jul 24.
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8.) Ruder EH, Hartman TJ, Blumberg J, Goldman MB. Oxidative stress and antioxidants: exposure and impact on female fertility. Hum Reprod Update. 2008 Jul-Aug;14(4):345-57. Epub 2008 Jun 4.9.) Agarwal A, Saleh RA. Role of oxidants in male infertility: rationale, significance, and treatment. Urol Clin North Am. 2002 Nov;29(4):817-27.
10.) Aitken RJ, Buckingham D, Harkiss D. Use of a xanthine oxidase free radical generating system to investigate the cytotoxic effects of reactive oxygen species on human spermatozoa. J Reprod Fertil. 1993 Mar;97(2):441-50.
11.) Armstrong JS, Rajasekaran M, Chamulitrat W, Gatti P, Hellstrom WJ, Sikka SC. Characterization of reactive oxygen species induced effects on human spermatozoa movement and energy metabolism. Free Radic Biol Med. 1999 Apr;26(7-8):869-80.
12.) Athayde KS, Cocuzza M, Agarwal A, Krajcir N, Lucon AM, Srougi M, Hallak J. Development of normal reference values for seminal reactive oxygen species and their correlation with leukocytes and semen parameters in a fertile population. J Androl. 2007 Jul-Aug;28(4):613-20. Epub 2007 Apr 4.
13.) Aziz N, Saleh RA, Sharma RK, Lewis-Jones I, Esfandiari N, Thomas AJ Jr, Agarwal A.Novel association between sperm reactive oxygen species production, sperm morphological defects, and the sperm deformity index.Fertil Steril. 2004 Feb;81(2):349-54.
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41.) Rahman MM, Ichiyanagi T, Komiyama T, Hatano Y, Konishi T. Superoxide radical- and peroxynitrite-scavenging activity of anthocyanins; structure-activity relationship and their synergism. Free Radic Res. 2006 Sep;40(9):993-1002.
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76.) 38.) Milbury PE, Graf B, Curran-Celentano JM, Blumberg JB. Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells. Invest Ophthalmol Vis Sci. 2007 May;48(5):2343-9.
77.) 39.) Katsube N, Iwashita K, Tsushida T, Yamaki K, Kobori M. Induction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins. J Agric Food Chem. 2003 Jan 1;51(1):68-75.

 

 

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