Maxi Marine O-3
High Potency Enteric Coated Ultra-Pure Essential Fatty Acids From Norwegian Arctic-Harvested Fish
Maxi Marine O-3 is an ultra-pure, ultra-high potency
fish oil from anchovies and sardines harvested in pristine Norwegian Arctic waters. Purity is further assured by molecular distillation and every batch is verified by an independent third-party lab to be free of PCB's, heavy metals and pesticides. Vitamin E (mixed tocopherols) is added to maintain maximum freshness and enteric coating ensures no "fishy" after-taste.
EPA and DHA, the "active ingredients" in fish oil, are long-chain Omega-3 Essential Fatty Acids that differ from short-chain Omega-3's found in plant sources. EPA and DHA are beneficial for Cardiovascular (Heart) Health, Alzheimer’s Disease and other Dementias, Mental Health, Child Development, Attention-Deficit Disorders and Social/Cognitive Development, Diabetes, Inflammatory Diseases (rheumatoid arthritis, IBS/Crohn’s, asthma, infertility, etc.) and Cancer.
EPA/DHA (which occur together in fish oils) have numerous studies supporting their antiinflammatory properties and use in multiple hyper-inflammatory and autoimmune states. (14-24) EPA and DHA decrease NK cell activity (14,24-29), and this effect is synergistic when both EPA and DHA are used together.(18,28). EPA, but not ALA, also decreases TNF-alpha.(23-25).
While ALA (flax oil) has some similar benefits, it must be taken in significantly higher doses because ultimately the anti-inflammatory effect is seen when ALA is converted to EPA, as follows:
ALA (flax oil) >>> SDA (stearidonic acid) >>> EPA (fish oil) >>> Prostaglandin E3
An estimated 0.07% of ALA is converted to EPA in healthy people (30,31), but the conversion rate may be less when the delta-6-desaturase (d6d) enzyme is underfunctioning or when there is high competition from dietary Omega-6's (both use the d6d enzyme). Assuming that converting enzymes are normal in a fertility clinic patient, a dose comparison would be 14 grams of flax oil vs. 1 grams of fish oil.
Studies have shown that ALA increases EPA but not DHA.(31) Some studies have shown that ALA does not reduce inflammatory markers (23,29). For these reasons, fish oil is preferrable to flax oil for raising EPA/DHA levels (33).
A very informative page about fish oil is found at the US Government website Medline. This page, from the NIH (National Institutes of Health) has an extensive list of uses and dosages with full references at this link:http://www.nlm.nih.gov/medlineplus/druginfo/natural/993.html
Maxi Marine O3 (Fish Oil) and it's use in CHF (Congestive Heart Failure):
"...Fish oil may decrease cardiac afterload by an antivasopressor action and by reducing blood viscosity, may reduce arrhythmic risk despite supporting the heart's beta-adrenergic responsiveness, may decrease fibrotic cardiac remodeling by impeding the action of angiotensin II and, in patients with coronary disease, may reduce the risk of atherothrombotic ischemic complications. Since the measures recommended here are nutritional and carry little if any toxic risk, there is no reason why their joint application should not be studied as a comprehensive nutritional therapy for congestive heart failure. ..."
Suggested Use: Adults take one or two capsules daily with meals or more if directed by your health care provider.
Please note that the EPA/DHA content of Maxi Marine O-3 (700mg total) is two and a half times more concentrated than most fish oils.
Dr. Myatt's Comment:
Fish oil can be taken as an OTC supplement like Maxi Marine O3 or prescribed as an exorbitantly expensive "drug" Lovaza: http://www.lovaza.com/. The "drug" Lovaza costs about $200/month compared to around $20/month for Maxi Marine O3. The Rx. version is only slightly more potent than the OTC; there is no other "magic" about it.
Marine Lipid Concentrate: 1000mg - which provides:
EPA (eicosapentaenoic acid) 420mg
DHA (docosahexaenoic acid) 280mg
Because Maxi Marine is so concentrated it is a much more economical choice for those using higher doses of these important oils. Our regular brand of Ultra-Pure Fish Oil costs approximately 67 cents per gram while our higher-potency Maxi Marine O-3 is only 58 cents per gram. Higher potency means fewer capsules per day, representing significant cost savings.
STORAGE: Store in a cool place and keep out of reach of children.
Contains No wheat, gluten, corn protein, yeast, dairy, artificial colors, sweeteners or preservatives.
Product # N311 - Maxi Marine O3 - 120 softgels - $54.95
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14.) Mukaro VR, Costabile M, Murphy KJ, Hii CS, Howe PR, Ferrante A. Leukocyte numbers and function in subjects eating n-3 enriched foods: selective depression of natural killer cell levels. Arthritis Res Ther. 2008;10(3):R57. Epub 2008 May 14.
CONCLUSION: The data show that regular long-term consumption of n-3 enriched foods leads to lower numbers of NK cells and neutrophil iodination activity but higher lymphotoxin production by lymphocytes. These changes are consistent with decreased inflammatory reaction and
tissue damage seen in patients with inflammatory disorders receiving n-3 LCPUFA supplementation.
15.) Calder PC. Dietary modification of inflammation with lipids. Proc Nutr Soc. 2002 Aug;61(3):345-58. CONCLUSION: EPA is anti-inflammatory
16.) Calder PC. N-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. Lipids. 2003 Apr;38(4):343-52.
CONCLUSION: EPA is anti-inflammatory
17.) Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr. 2002 Dec;21(6):495-505.
CONCLUSION: Fish oil more biologically active than ALA; anti-inflammatory properties; useful in RA and MS among others
18.) Calder PC. Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on 'Nutrition and autoimmune disease' PUFA, inflammatory processes and rheumatoid arthritis. Proc Nutr Soc. 2008 Nov;67(4):409-18.
CONCLUSION: fish oil (both EPA and DHA) are anti-inflammatory
19.) Rupp H, Wagner D, Rupp T, Schulte LM, Maisch B. Risk stratification by the "EPA+DHA level" and the "EPA/AA ratio" focus on anti-inflammatory and antiarrhythmogenic effects of long-chain omega-3 fatty acids. Herz. 2004 Nov;29(7):673-85.
CONCLUSION: DOSE:2-4 g/day of 84% EPA+DHA ethyl esters for anti-inflammatory effects
20.) Cleland LG, Caughey GE, James MJ, Proudman SM. Reduction of cardiovascular risk factors with longterm fish oil treatment in early rheumatoid arthritis.J Rheumatol. 2006 Oct;33(10):1973-9. Epub 2006 Aug 1.
CONCLUSION: anti-inflammatory effects of fish oil in RA patients; also reduced NSAID use with fish oil
21.) Cleland LG, James MJ, Proudman SM. The role of fish oils in the treatment of rheumatoid arthritis. Drugs. 2003;63(9):845-53.
CONCLUSION: fish oil anti-inflammatory in RA
22.) Kremer JM, Lawrence DA, Petrillo GF, Litts LL, Mullaly PM, Rynes RI, Stocker RP, Parhami N, Greenstein NS, Fuchs BR, et al. Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs. Clinical and immune correlates. Arthritis
Rheum. 1995 Aug;38(8):1107-14. CONCLUSION: Fish oil anti-inflammatory in RA
23.) Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Willett WC, Rimm EB. Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation. 2003 Jul 15;108(2):155-60. Epub 2003 Jun 23.
CONCLUSION: Fish oil but not ALA associated with decreased inflammatory markers; Fish oil decreased TNF
24.) Ferrucci L, Cherubini A, Bandinelli S, Bartali B, Corsi A, Lauretani F, Martin A, Andres-Lacueva C, Senin U, Guralnik JM. Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers. J Clin Endocrinol Metab. 2006 Feb;91(2):439-46. Epub 2005 Oct 18. CONCLUSION: Higher EFA's accociated with lower inflammatory markers; n-3 lowers TNF-alpha and inflammation
25.) Sundrarjun T, Komindr S, Archararit N, Dahlan W, Puchaiwatananon O, Angthararak S, Udomsuppayakul U, Chuncharunee S. Effects of n-3 fatty acids on serum interleukin-6, tumour necrosis factor-alpha and soluble tumour necrosis factor receptor p55 in active rheumatoid
arthritis. J Int Med Res. 2004 Sep-Oct;32(5):443-54. CONCLUSION: Fish oil decreaases TNF-alpha, soluble tumour necrosis factor receptor p55 (sTNF-R p55), CPR and I-6 in RA patients
26.) Yamashita N, Sugiyama E, Hamazaki T, Yano S.Inhibition of natural killer cell activity by eicosapentaenoic acid in vivo and in vitro.Biochem Biophys Res Commun. 1988 Jan 15;150(1):497-505. CONCLUSION: EPA decreases NK activity
27.) Yamashita N, Yokoyama A, Hamazaki T, Yano S. Inhibition of natural killer cell activity of human lymphocytes by eicosapentaenoic acid. Biochem Biophys Res Commun. 1986 Aug 14;138(3):1058-67. CONCLUSION: EPA decreases NK activity
28) Yamashita N, Maruyama M, Yamazaki K, Hamazaki T, Yano S. Effect of eicosapentaenoic and docosahexaenoic acid on natural killer cell activity in human peripheral blood lymphocytes. Clin Immunol Immunopathol. 1991 Jun;59(3):335-45.
CONCLUSION: EPA and DHA both inhibit NK cell activity; the effect is greater (synergistic) when both are used together
29.) Thies F, Nebe-von-Caron G, Powell JR, Yaqoob P, Newsholme EA, Calder PC. Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y. Am J Clin Nutr. 2001 Mar;73(3):539-48.
CONCLUSION: NK cell activity was not significantly affected by the placebo, ALA, GLA, AA, or DHA treatment. Fish oil caused a significant reduction (mean decline: 48%) in NK cell activity that was fully reversed by 4 wk after supplementation had ceased. CONCLUSION: A moderate amount of EPA but not of other n-6 or n-3 polyunsaturated fatty acids can decrease NK cell activity in healthy subjects." DOSE: 1 g EPA plus DHA (720 mg EPA + 280 mg DHA) daily
30.) James MJ, Ursin VM, Cleland LG. Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. Am J Clin Nutr. 2003 May;77(5):1140-5. CONCLUSION: increases of EPA from various sources was 1:0.3:0.07 for EPA:SDA:ALA.
31.) Wallace FA, Miles EA, Calder PC. Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects. Br J Nutr. 2003 May;89(5):679-89. CONCLUSION: ALA increases EPA but not DHA; higher dose needed
32.) Arterburn LM, Hall EB, Oken H. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr. 2006 Jun;83(6 Suppl):1467S-1476S. CONCLUSION: ALA not well-converted to EPA and DHA; DOSE: DHA 2 g/day for maximal tissue response
33.) Young GS, Conquer JA, Thomas R. Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder. Reprod Nutr Dev. 2005 Sep-Oct;45(5):549-58. CONCLUSION: fish oil prefferable to flax oil for raising EPA/DHA levels and decreasing AA/EPA ratios