Grape Seed Extract
(OPC’s, Oligomeric proanthocyanidins)

Protect Yourself From Cancer, Heart Disease, and Diabetes with One of Nature’s Most Potent Antioxidants

Oligomeric proanthocyanidins (OPC’s), found in many plants but primarily in grape seed extract and pine bark, is a potent antioxidant with 50 times more antioxidant power than vitamin E and 20 times more than vitamin C. 2,3,19 Grape Seed Extract has more of the active ingredient, proanthocyanidins, than products extracted from pine bark.1

Studies performed over the last 25 years have demonstrated that OPC’s exert the following effects.

Grape Seed Extract (OPC’s) may prevent heart disease through a variety of mechanisms including :

• potent antioxidant effects 5-14
• vaso-relaxant effects (relaxes blood vessels) 13,15-16, 26
• decreasing platelet “stickiness” 17-18
• protects again myocardial reperfusion injury 19
• limits LDL oxidation 8, 20-25
• improves microcirculation 13, 27-28
• anti-inflammatory effects 11, 29-31
• strengthens blood vessels (useful in chronic venous insufficiency) 32-37

Grape Seed Extract (OPC’s) may be useful in both cancer prevention and treatment because of its antioxidant effects

• help prevent cancerous cellular changes (5-14)
• anti-carcinogenic and chemoprotective effects (10,14,19, 38)
• inducing apoptosis in cancer cells (cell death) (39-41,58)
• decreasing toxicity of many cancer drugs (10,19, 42-47)
•  potentiates (increases) the effect of some cancer drugs while decreasing toxicity (44, 47-49)

Because OPC’s help strengthen collagen (50-54) which may increase elasticity of skin, muscles, tendons and ligaments many people take grape seed extract as part of their skin rejuvenation program.

Grape Seed Extract has anti-histamine properties (it stabilizes the release of histamine from mast cells). (55-57) Grape seed extract can be used like an antihistamine but without any of the typical drug-antihistamine side effects such as drowsiness.

Because of its many actions, Grape seed extract (OPC’s) may also be useful for:

• arthritis (anti-inflammatory and collagen strengthening)
• respiratory allergies (antihistamine)
• food allergies (antihistamine)
• ADHD (many cases are allergy-related)
• longevity and rejuvenation programs (blood viscosity and collagen-strengthening effects)

Suggested Dose: 50 to 100 mg grape seed extract, 2-3 times per day with meals.

Each one (1) Capsule contains:

Grape seed extract 100 mg
Grape skin extract 100 mg

References

1.) SUMMARY OF DATA FOR CHEMICAL SELECTION
Oligomeric Proanthocyanidins from Grape Seeds and Pine Bark. National Institutes of Health, 2000.http://ntp.niehs.nih.gov/ntp/htdocs/Chem_Background/ExSumPdf/GrapeSeeds_PineBark.pdf
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46.) Joshi SS, Kuszynski CA, Benner EJ, Bagchi M, Bagchi D. Amelioration of the cytotoxic effects of chemotherapeutic agents by grape seed proanthocyanidin extract. Antioxid Redox Signal. 1999 Winter;1(4):563-70.
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