Licorice – DGL
(Deglycyrrhinated Licorice)

Natural, Soothing Stomach Protection

Rhizinate 3X deglycyrrhizinated licorice

Licorice increases the stomach’s production of protective mucous. In sensitive individuals, however, licorice may elevate blood pressure. Deglycyrrhinated licorice (DGL) retains the stomach-protective benefits without affecting blood pressure. DGL Licorice helps prevent heartburn without diminishing stomach acid production.

Suggested dose: 1-2 tabs, 2-3 times per day before meals or as needed.

Product # 828 Rhizinate 3x German Chocolate 90 chewable tabs $16.50

Rhizinate 3X deglycyrrhizinated licorice is a unique 10:1 extract of deglycyrrhizinated licorice with a delicious, German Chocolate flavor. DGL is widely used in Europe and first introduced to the United States in 1986.

Rhizinate 3X supports overall health of the gastrointestinal system along with the lining of the stomach and intestinal tract.†

Rhizinate 3X provides the best-tasting DGL on the market. In a blind taste test, participants chose Rhizinate 3X by at least 87 percent over other leading competitors. In fact, every participant chose Rhizinate 3X over one comparably-concentrated brand.1

Rhizinate 3X provides the following benefits:

• Glycyrrhizic acid-free formula provides only the beneficial effects of licorice†
• Chewable formula works naturally with enzymes in saliva to support digestive health†
• Best tasting DGL; great German-chocolate flavor
• Helps relieve stomach discomfort by stimulating and accelerating natural protective factors in the digestive tract†
• Boosts the production of mucin, a natural compound that coats and protects the lining of the stomach and intestines†
• Potent 10:1 extract; provides immediate benefits and maximum absorption in chewable form†
• Includes glycine to help keep the stomach lining strong†

How Does It Work?

Licorice is one of the oldest traditionally used plants in the world. While the plant’s origins are in the Mediterranean, the Middle East and central Asia, for centuries it has been cultivated virtually everywhere from Spain to China.2,3

Licorice root contains glycyrrhizic acid, which has many beneficial properties but can lead to high blood pressure if consumed in large quantities over an extended period of time.†4,5 Glycyrrhizic acid has been used to support immunity and liver function for many years.6 However, because the beneficial effects of licorice on the stomach lining are not solely dependent upon the glycyrrhizic acid, it has been removed.† Deglycyrrhizinated licorice (DGL) provides the beneficial effects of supporting gastrointestinal health without the unpleasant side effects.†

Rhizinate 3X helps support healthy mucosal lining by stimulating the stomach’s natural protective factors.†7,8 The stomach and upper sections of the small intestines are lined with thin layers of tissue called the mucosa. This lining must function in the stomach’s extreme acid environment of pH levels ranging around 2.0 to 3.0. DGL does not protect the stomach lining by suppressing gastric acid. Rather, it stimulates increased mucous production and blood supply to the mucosa.†9,10

With 30 years of use and scientific and clinical studies showing gastrointestinal support, DGL has been safely recommended for short-term and long-term use.†11,13

In an internal clinical study, participants found Rhizinate 3X to be just as or more effective than the DGL product they currently use.† They also commented on the delicious flavor of Rhizinate 3X.12

Additional Benefits of Licorice:

• Licorice is a rich source of flavonoids and isoflavonoids that have significant antioxidant activities.†13
• Licorice supports beneficial levels of microbes and bacteria.† In one study, licorice inhibited nitric oxide production in macrophages (white blood cells) and increased the longevity in an animal model.†14
• In a clinical trial, deglycyrrhizinated licorice supported healthy mouth tissue in 75% of participants.† Benefits were seen in only one day.15
  Note:DGL mixes with salivary compounds that may enhance its effects (bioavailability/absorption). Therefore, chewable preparations are preferred.16

Glycine

Glycine is a stable amino acid that has the ability to support healthy mucosal lining of the stomach.†17 It is also a glutathione precursor. Glutathione is one of the body’s natural antioxidants.17

DGL is a natural, clinically-studied ingredient that has been used to support healthy digestive function for over 30 years.† Rhizinate 3X provides a great-tasting, chewable tablet that works with digestive enzymes in saliva to provide benefits to the stomach and intestinal mucosa.†

Ingredients and Nutrition Facts

This product does not contain

• artificial coloring
• artificial flavoring
• corn
• gluten
• preservatives
• wheat
• yeast

This product contains natural ingredients; color variations are normal.

Note: If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

Other Ingredients: natural flavors (soy lecithin, coconut, and milk), fructose, organic inulin, silicon dioxide, and organic guar gum.

† This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

References

1. DGL Taste Comparison. Unpublished data. May 2008
2. Blumenthal M., ed. “Licorice.” In:Herbal Medicine: Expanded Commission E Monographs. American Botanical Council. Austin, TX. 2000; 233-239.
3. Turpie AGG, Runcie J, Thomson TJ. Clinical trial of dglycyrrhizinized liquorice in gastric ulcer.Gut. 1969;10:299-302.
4. Stormer FC, Reistad R, Alexander J. Glycyrrgizic Acid in Liquorice: Evaluation of Health Hazard. Fd Chem Toxic. 1993;31:303-312.
5. Heikens J, Fliers E, Endert E, Ackermans M, van Montfrans G. Liquorice-induced hypertension-a new understanding of an old disease: case report and brief review.Netherlands J Med. 1995;47:230-234.
6. Murray MT, Pizzorno JE. Ulcers (Duodenal and Gastric). In:Encyclopedia of Natural Medicine Revised 2nd Edition. Rocklin, Calif: Prima Publishing;1998:516-517, 208-209.
7. Morgan AG, et al. Comparison between Cimetidine and [deglycyrrhizinated licorice] in the treatment of gastric ulceratioonn and subsequent maintenance therapy.Gut. 1982;23:545-51.
8. Turpie AG, Runcie J, Thomson TJ. Clinical trial of dglycyrrhizinized liquorice in gastric ulcer.Gut. 1969;10:299-302.
9. Whiting B, Thomson TJ. Deglycyrrhizinized liquorice in duodenal ulcer.Br Med J. 1971 Oct 2;4(5778):48.
10. Van Marle J, Aarsen PN, Lind A, van Weeren-Kramer J. Deglycyrrhizinised liquorice (DGL) and the renewal of rat stomach epithelium.Eur J Pharmacol. 1981 Jun 19;72(2-3):219-25.
11. Turpie AGG, Runcie J, Thomson TJ. Clinical trial of dglycyrrhizinized liquorice in gastric ulcer.Gut. 1969;10:299-302.
12. DGL Comparison Study. Unpublished data. May 2008.
13. Licorice. In: Fleming T., ed.PDR®for Herbal Medicines. Montvale, NJ: Medical Economics Company; 2000: 510-519.
14. Kang JS, Yoon YD, Cho IJ, Han MH, Lee CW, Park SK, Kim HM. Glabridin, an isoflavan from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock.J Pharmacol Exp Ther. 2005 Mar;312(3):1187-94.
15. Das SK, Das V, Gulati AK, Singh VP. Deglycyrrhizinated liquorice in aphthous ulcers.J Assoc Physicians India. 1989 Oct;37(10):647.
16. Murray MT, Pizzorno JE. Ulcers (Duodenal and Gastric). In:Encyclopedia of Natural Medicine Revised 2nd Edition. Rocklin, Calif: Prima Publishing;1998:817.
17. Tariq M, Al Moutaery AR. Studies on the antisecretory, gastric anti-ulcer and cytoprotective properties of glycine.Res Commun Mol Pathol Pharmacol. 1997;97(2):185-98.