B-12 Extreme

The Most Potent Vitamin B-12 Supplement Available

Vitamin B-12 Deficiencies Are Common and Effects Widespread

Even minor deficiencies of Vitamin B-12 can effect nearly every system in the body including:

•  Energy. Deficiencies of vitamin B-12 can cause anemia, fatigue, shortness of breath and weakness.
• The Nervous System.  B-12 deficiency causes neurological changes including numbness and tingling in the hands and feet,  balance problems, depression, confusion, poor memory and Alzheimer’s-like symptoms. Long-term deficiencies of B-12 can result in permanent impairment of the nervous system.
• The Gastro-Intestinal System. B-12 deficiency can cause decreased appetite, constipation, diarrhea or alternating constipation / diarrhea, weight loss and abdominal pain.
• The Immune System. Vitamin B-12 is necessary for normal functioning of white blood cells. Studies show that B-12 helps regulate Natural-Killer T-cells and prevents chromosome damage.
• The Cardiovascular System. Vitamin B-12 participates in the conversion of homocysteine to methionine. Elevated homocysteine levels are a known independent risk factor for heart attack, stroke and thrombosis. Without adequate B-12 levels, homocysteine levels typically rise.
• Special Senses: degenerative changes in the central nervous system caused by B-12 deficiency can also affect the optic nerve, resulting in blue-yellow color blindness.
• In Infants and Children, signs of vitamin B-12 deficiency include failure to thrive, movement disorders, delayed development, and megaloblastic anemia.

Vitamin B-12 deficiency can be present before blood tests reveal the deficiency.

Four Forms of B-12 — Which One is Best?

Cobalamin is a collective term for four closely related forms of B-12 — cyanocobalamin, methylcobalamin, hydroxycobalamin, and adenosylcobalamin (dibencozide).

Cyanocobalamin, the most common form of B-12 found in nutritional supplements, has the lowest biological activity and must be converted in the liver to methylcobalamin or adenosylcobalamin before it can be utilized.

Because it can be converted to other forms of B-12, cyanocobalamin can be considered the “mother form” of B-12. However, this conversion is inefficient and some people may not benefit cyanocobalamin due to lack of assimilation or conversion.

Methylcobalamin is considered by many researchers to be the most active form of vitamin B-12. It protects the nervous system by regulating glutamate- induced neuronal damage (common in aging)  and promoting nerve cell regeneration.

Methylcobalamin is the only form of vitamin B-12 that participates in regulating circadian rhythms (sleep/wake cycles). It has been shown to improve sleep quality and refreshment from sleep, as well as increasing feelings of well-being, concentration and alertness.

Adenosylcobalamin (dibencozide), the second highly active form of vitamin B-12, is essential for energy metabolism. It is required for normal myelin sheath formation and nucleoprotein synthesis. Deficiencies are associated with nerve and spinal cord degeneration.

Hydroxocobalamin is a unique form of B-12 that participates in detoxification, especially cyanide detoxification. Cyanide levels are often elevated in smokers, people who eat cyanide-containing food (like cassava) and those with certain metabolic defects.

Excess cyanide in the tissues blocks conversion of cyanocobalamin to methylcobalamin or adenosylcobalamin. In such instances, hydroxocobalamin may be the vitamin B-12 of choice. Hydroxycobalamin is FDA- approved as a treatment for cyanide poisoning.

Given the subtle yet important differences between these forms of B-12, an ideal formula might be one which contains all four forms.

Oral Vs. Injectable: Which Delivery System is Preferred?

Although many people including some physicians still believe that injectable vitamin B-12 is the preferred route of administration, it is well-known and widely accepted that oral vitamin B-12 is equally as effective as injection in treating pernicious anemia and other B-12 deficient states.

B-12 Extreme: All 4 Forms of Vitamin B-12, Highest Potency Available

Product & Usage Information:

• Daily Use: Take one tablet, once or twice daily as a dietary supplement, or as recommended by your health care provider. Allow tablet to fully dissolve under tongue.
• Inactive Ingredients: Sorbitol, Natural Strawberry Flavor, Natural Color, Magnesium Stearate, Silicon Dioxide

B-12 Extreme: 35 mg (35,000 mcg), 30 sublingual tablets. $44.97

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