Berberine 500mg 60 capsules

Description

Powerful effects on blood sugar, cholesterol, heart disease and cancer

Berberine is an alkaloid derived from various plants including Goldenseal (Hydrastis canadensis), Oregon grape (Berberis aquifolium), Barberry (Berberis vulgaris), Chinese Goldenthread (Coptis) and other plants. It has a bright yellow color.

Same potency, now in ONE capsule instead of two!
Previous formula: 120 caps per bottle, 2 caps = 500mg (60 doses per bottle)
Now: 60 caps per bottle, 1 cap = 500mg (60 doses per bottle)

Actions of Berberine:

Broad-spectrum anti-microbial: (1-6, 60)
Berberine has been found to be an effective against:

• Chlamydia
• Candida (multiple species)
• E. coli
• Salmonella typhi
• Entamoeba histolytica
• Staphylococcus aureus
• Streptococcus sanguis
• Pseudomonas aeruginosa
• Helicobacter pylori
• other Gram-positive bacteria and fungi
• Some studies suggest that goldenseal may also be effective against viruses, fungi, protozoans, helminths (worms) and MRSA (methicillin-resistant Staphylococcus
  aureus)

Blood sugar regulation / diabetes type II. Some studies have shown that berberine lowers blood sugar as effectively as the diabetes drug metformin. (7-18)

Cholesterol-lowering effects. Studies show lipid-lowering effects on total cholesterol, triglyceride and LDL cholesterol. (19-26)

Cardic effects. Berbeine has been found to have anti-arrhythmic effects and may also be useful for CHF (congestive heart failure). (27-34)

Anti-cancer effects. Berberine has been found to have anti-neoplastic effects against a wide variety of cancer cell types including brain, bladder, breast, bone, colon, liver, lung, prostate, skin cancer and leukemia. (35-59)

Learn More about Berberine in our HealthBeat News article:
The “Swiss Army Knife” Of Supplements

Berberine 500 mg of Berberine per each capsules.

Suggested Use As a dietary supplement:

For antimicrobial effect: Take one capsule two times daily for up to fourteen (14) days with water at mealtimes. Not to be taken by pregnant or lactating women or children under 12 years old.

For blood sugar regulation: one capsule, 3 times daily with meals.

N361 – Berberine 500mg – 60 vegetarian caps – $34.97

Product description: Berberine 500mg 60 vegetarian caps

Ingredients per capsule:
Berberine HCL 500 mg (Extracted from Berberis Aristata, root)
Calcium (as calcium carbonate) 35mg

Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose and water) and silicone dioxide.

Capsule: Vegetable source from cellulose, preservative free.

Hypoallergenic: Contains NO yeast, wheat, gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives, or flavoring.

100% Vegetarian Formula

Bottle contains both a desiccant and an anti-oxidant packet to protect the contents from degradation due to moisture and oxidation

References

1.) Hahn FE, Ciak J. Berberine. Antibiotics 1976;3:57788.
2.) Kim SH, Lee SJ, Lee JH, Sun WS, Kim JH. Antimicrobial activity of 9-O-acyl- and 9-O-alkylberberrubine derivatives. Planta Med. 2002 Mar;68(3):277-81.
3.) Scazzocchio F, Cometa MF, Tomassini L, Palmery M. Antibacterial activity of Hydrastis canadensis extract and its major isolated alkaloids. Planta Med. 2001 Aug;67(6):561-4.
4.) Mahady GB, Pendland SL, Stoia A, Chadwick LR. In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis.Phytother Res. 2003 Mar;17(3):217-21.
5.) [no authors listed]. Berberine. Altern Med Rev. 2000 Apr;5(2):175-7.
Berberine. Altern Med Rev. Apr 2000;5(2):175-177.
6.) Yu HH, Kim KJ, Cha JD, et al. Antimicrobial activity of berberine alone and in
combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus
aureus. J Med Food. Winter 2005;8(4):454-461.
7.) Chen C, Zhang Y, Huang C. Berberine inhibits PTP1B activity and mimics
insulin action. Biochem Biophys Res Commun. Jul 2 2010;397(3):543-547.
8.) Turner N, Li JY, Gosby A, et al. Berberine and its more biologically available
derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a
mechanism for the action of berberine to activate AMP-activated protein kinase
and improve insulin action. Diabetes. May 2008;57(5):1414-1418.
9.) Lee YS, Kim WS, Kim KH, et al. Berberine, a natural plant product, activates
AMP-activated protein kinase with beneficial metabolic effects in diabetic and
insulin-resistant states. Diabetes. Aug 2006;55(8):2256-2264.
10.) Ma X, Egawa T, Kimura H, et al. Berberine-induced activation of 5’-adenosine
monophosphate-activated protein kinase and glucose transport in rat skeletal
muscles. Metabolism. Apr 26 2010.
11.) Hwang JT, Kwon DY, Yoon SH. AMP-activated protein kinase: a potential target
for the diseases prevention by natural occurring polyphenols. N Biotechnol. Oct
1 2009;26(1-2):17-22.
12.) Zhang H, Wei J, Xue R, et al. Berberine lowers blood glucose in type 2 diabetes
mellitus patients through increasing insulin receptor expression. Metabolism. Feb
2009;59(2):285-292.
13.) Kong WJ, Zhang H, Song DQ, et al. Berberine reduces insulin resistance
through protein kinase C-dependent up-regulation of insulin receptor expression.
Metabolism. Jan 2009;58(1):109-119.
14.) Yin J, Gao Z, Liu D, Liu Z, Ye J. Berberine improves glucose metabolism
through induction of glycolysis. Am J Physiol Endocrinol Metab. Jan
2008;294(1):E148-156.
15.) Lu SS, Yu YL, Zhu HJ, et al. Berberine promotes glucagon-like peptide-1
(7-36) amide secretion in streptozotocin-induced diabetic rats. J Endocrinol. Feb
2009;200(2):159-165.
16.) Yu Y, Liu L, Wang X, Liu X, Xie L, Wang G. Modulation of glucagon-like
peptide-1 release by berberine: in vivo and in vitro studies. Biochem Pharmacol.
Apr 1 2009;79(7):1000-1006.
17.) Al-masri IM, Mohammad MK, Tahaa MO. Inhibition of dipeptidyl peptidase
IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of
berberine. J Enzyme Inhib Med Chem. Oct 2009;24(5):1061-1066.
18.) Yin J., Xing H., Ye J. Efficacy of Berberine in Patients with Type 2 Diabetes. Metabolism. 2008 May; 57(5): 712717.
19.) Abidi P, Chen W, Kraemer FB, Li H, Liu J. The medicinal plant goldenseal is a natural  LDL-lowering agent with multiple bioactive components and new action mechanisms.
J Lipid Res. 2006 Oct;47(10):2134-47. Epub 2006 Aug 2.
20.) Brusq JM, Ancellin N, Grondin P, Guillard R, Martin S, Saintillan Y, Issandou M.
Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the  hypolipidemic effects of berberine. J Lipid Res. 2006 Jun;47(6):1281-8. Epub 2006 Feb 28.
21.) Doggrell SA. Berberine–a novel approach to cholesterol lowering. Expert Opin Investig Drugs.  2005 May;14(5):683-5. [XXXanti-arrhythmic###]
22.) Kim WS, Lee YS, Cha SH, Jeong HW, Choe SS, Lee MR, Oh GT, Park HS, Lee KU, Lane MD,  Kim JB. Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK  activity. Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E812-9. Epub 2009 Jan 27.
23.)  Kong W, Wei J, Abidi P, Lin M, Inaba S, Li C, Wang Y, Wang Z, Si S, Pan H, Wang S, Wu J,  Wang Y, Li Z, Liu J, Jiang JD. Berberine is a novel cholesterol-lowering drug working through a  unique mechanism distinct from statins. Nat Med. 2004 Dec;10(12):1344-51. Epub 2004 Nov 7.
24.) Kong WJ, Wei J, Zuo ZY, Wang YM, Song DQ, You XF, Zhao LX, Pan HN, Jiang JD.
Combination of simvastatin with berberine improves the lipid-lowering efficacy. Metabolism. 2008  Aug;57(8):1029-37.
25.) Lee S, Lim HJ, Park JH, Lee KS, Jang Y, Park HY. Berberine-induced LDLR up-regulation  involves JNK pathway. Biochem Biophys Res Commun. 2007 Nov 3;362(4):853-7. Epub 2007 Aug  27.
26.) Li YH, Yang P, Kong WJ, Wang YX, Hu CQ, Zuo ZY, Wang YM, Gao H, Gao LM, Feng YC,  Du NN, Liu Y, Song DQ, Jiang JD. Berberine analogues as a novel class of the  low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and  cholesterol-lowering efficacy. J Med Chem. 2009 Jan 22;52(2):492-501.
27.) Lau CW, Yao XQ, Chen ZY, Ko WH, Huang Y. Cardiovascular actions of berberine.
Cardiovasc Drug Rev. 2001 Fall;19(3):234-44.
28.) Li BX, Yang BF, Zhou J, Xu CQ, Li YR. Inhibitory effects of berberine on IK1, IK, and HERG  channels of cardiac myocytes. Acta Pharmacol Sin. 2001 Feb;22(2):125-31.
29.) Wang LH, Yu CH, Fu Y, Li Q, Sun YQ. Berberine elicits anti-arrhythmic effects via IK1/Kir2.1  in the rat type 2 diabetic myocardial infarction model. Phytother Res. 2011 Jan;25(1):33-7. doi:  10.1002/ptr.3097.
30.) Wang YX, Yao XJ, Tan YH. Effects of berberine on delayed afterdepolarizations in ventricular  muscles in vitro and in vivo. J Cardiovasc Pharmacol. 1994 May;23(5):716-22.
31.) Hong Y, Hui SS, Chan BT, Hou J. Effect of berberine on catecholamine levels in rats with  experimental cardiac hypertrophy. Life Sci. 2003 Apr 18;72(22):2499-507.
32.) Hong Y, Hui SC, Chan TY, Hou JY. Effect of berberine on regression of pressure-overload  induced cardiac hypertrophy in rats. Am J Chin Med. 2002;30(4):589-99.
33.) Marin-Neto JA, Maciel BC, Secches AL, Gallo Júnior L. Cardiovascular effects of berberine in  patients with severe congestive heart failure.Clin Cardiol. 1988 Apr;11(4):253-60.
34.) Zeng XH, Zeng XJ, Li YY. Efficacy and safety of berberine for congestive heart failure  secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 2003 Jul 15;92(2):173-6.
35.) Chen TC, Lai KC, Yang JS, Liao CL, Hsia TC, Chen GW, Lin JJ, Lin HJ, Chiu TH, Tang YJ,  Chung JG. Involvement of reactive oxygen species and caspase-dependent pathway in  berberine-induced cell cycle arrest and apoptosis in C6 rat glioma cells. Int J Oncol. 2009  Jun;34(6):1681-90.
36.) Choi MS, Oh JH, Kim SM, Jung HY, Yoo HS, Lee YM, Moon DC, Han SB, Hong JT. Berberine  inhibits p53-dependent cell growth through induction of apoptosis of prostate cancer cells. Int J Oncol.  2009 May;34(5):1221-30.
37.) Eom KS, Kim HJ, So HS, Park R, Kim TY. Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction. Biol Pharm Bull. 2010;33(10):1644-9.
38.) Eom KS, Hong JM, Youn MJ, So HS, Park R, Kim JM, Kim TY. Berberine induces G1 arrest and  apoptosis in human glioblastoma T98G cells through mitochondrial/caspases pathway. Biol Pharm Bull.  2008 Apr;31(4):558-62.
39.) Hamsa TP, Kuttan G. Berberine Inhibits Pulmonary Metastasis through Down-regulation of MMP in Metastatic B16F-10 Melanoma Cells. Phytother Res. 2011 Sep 26. doi: 10.1002/ptr.3586. [Epub ahead of print]
40.) Ho YT, Yang JS, Lu CC, Chiang JH, Li TC, Lin JJ, Lai KC, Liao CL, Lin JG, Chung JG. Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model. Phytomedicine. 2009 Sep;16(9):887-90. Epub 2009 Mar 20.
41.) Hsu WH, Hsieh YS, Kuo HC, Teng CY, Huang HI, Wang CJ, Yang SF, Liou YS, Kuo WH.
Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL. Arch Toxicol. 2007 Oct;81(10):719-28. Epub 2007 Aug 3.
42.) Hwang JM, Kuo HC, Tseng TH, Liu JY, Chu CY. Berberine induces apoptosis through a  mitochondria/caspases pathway in human hepatoma cells. Arch Toxicol. 2006 Feb;80(2):62-73. Epub  2005 Sep 28.
43.) James MA, Fu H, Liu Y, Chen DR, You M. Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis. Mol Carcinog. 2011 Jan;50(1):1-7.
44.) Katiyar SK, Meeran SM, Katiyar N, Akhtar S. p53 Cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. Mol Carcinog. 2009 Jan;48(1):24-37.
45.) Kim S, Han J, Kim NY, Lee SK, Cho DH, Choi MY, Kim JS, Kim JH, Choe JH, Nam SJ, Lee  JE.Effect of berberine on p53 expression by TPA in breast cancer cells. Oncol Rep. 2012  Jan;27(1):210-5. doi: 10.3892/or.2011.1480. Epub 2011 Sep 29.
46.) Kim S, Choi JH, Kim JB, Nam SJ, Yang JH, Kim JH, Lee JE. Berberine suppresses  TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231  human breast cancer cells. Molecules. 2008 Dec 3;13(12):2975-85.
47.) Li J, Cao B, Liu X, Fu X, Xiong Z, Chen L, Sartor O, Dong Y, Zhang H. Berberine suppresses  androgen receptor signaling in prostate cancer. Mol Cancer Ther. 2011 Aug;10(8):1346-56. Epub 2011  May 25.
48.) Lin CC, Kao ST, Chen GW, Ho HC, Chung JG. Apoptosis of human leukemia HL-60 cells and  murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3. Anticancer  Res. 2006 Jan-Feb;26(1A):227-42.
49.) Liu B, Wang G, Yang J, Pan X, Yang Z, Zang L. Berberine inhibits human hepatoma cell invasion  without cytotoxicity in healthy hepatocytes. PLoS One. 2011;6(6):e21416. Epub 2011 Jun 24.
50.) Liu Z, Liu Q, Xu B, Wu J, Guo C, Zhu F, Yang Q, Gao G, Gong Y, Shao C. Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. Mutat Res. 2009 Mar 9;662(1-2):75-83. Epub 2008 Dec 31.
51.) Mantena SK, Sharma SD, Katiyar SK. Berberine, a natural product, induces G1-phase cell cycle  arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. Mol Cancer Ther. 2006  Feb;5(2):296-308.
52.) Mantena SK, Sharma SD, Katiyar SK. Berberine inhibits growth, induces G1 arrest and apoptosis  in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of  mitochondrial membrane potential and cleavage of caspase 3 and PARP. Carcinogenesis. 2006 Oct;  27(10):2018-27. Epub 2006 Apr 18.
53.) Meeran SM, Katiyar S, Katiyar SK. Berberine-induced apoptosis in human prostate cancer cells is  initiated by reactive oxygen species generation. Toxicol Appl Pharmacol. 2008 May 15;229(1):33-43.  Epub 2008 Jan 17.
54.) Patil JB, Kim J, Jayaprakasha GK. Berberine induces apoptosis in breast cancer cells (MCF-7) through mitochondrial-dependent pathway. Eur J Pharmacol. 2010 Oct 25;645(1-3):70-8. Epub 2010 Aug 4.
55.) Peng PL, Kuo WH, Tseng HC, Chou FP. Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: the contribution of autophagic cell death. Int J Radiat Oncol Biol Phys. 2008 Feb 1;70(2):529-42.
56.) Tan W, Li Y, Chen M, Wang Y. Berberine hydrochloride: anticancer activity and nanoparticulate  delivery system. Int J Nanomedicine. 2011;6:1773-7. Epub 2011 Aug 24.
57.) Yan K, Zhang C, Feng J, Hou L, Yan L, Zhou Z, Liu Z, Liu C, Fan Y, Zheng B, Xu Z. Induction  of G1 cell cycle arrest and apoptosis by berberine in bladder cancer cells. Eur J Pharmacol. 2011 Jul  1;661(1-3):1-7. Epub 2011 Apr 30.
58.) Yu FS, Yang JS, Lin HJ, Yu CS, Tan TW, Lin YT, Lin CC, Lu HF, Chung JG. Berberine inhibits WEHI-3 leukemia cells in vivo. In Vivo. 2007 Mar-Apr;21(2):407-12.
59.) Zhang RX, Dougherty DV, Rosenblum ML. Laboratory studies of berberine used alone and in combination with 1,3-bis(2-chloroethyl)-1-nitrosourea to treat malignant brain tumors. Chin Med J (Engl). 1990 Aug;103(8):658-65.
60.) Wei GX, Xu X, Wu CD. In vitro synergism between berberine and miconazole against planktonic and biofilm Candida cultures. Arch Oral Biol. 2011 Jun;56(6):565-72. Epub 2011 Jan 26.