Maxi Flavone™

Broad-Spectrum Herbal Formula

(Anti-inflammatory, Antioxidant and TNF-inhibiting)

Radical Oxygen Species (ROS), elevated TNF-alpha and inflammation are known to play a significant role in many cases of infertility in both men and women.

Radical Oxygen Species (ROS) and Infertility

Radical Oxygen Species (ROS, also called “free radicals”) include the hydroxyl radical, hydrogen peroxide, lipid peroxide, hypochlorite, chloramines, superoxide anion, peroxyl radical to name just a few. Inflammation is a primary cause of increased ROS.

In women, Radical Oxygen Species are detrimental to both natural and assisted fertility.1-8 ROS is also associated with polycystic ovarian disease, endometriosis, spontaneous abortions, preeclampsia, hydatidiform mole, embryopathies, preterm labor, and intrauterine growth retardation.2-3

In men, Radical Oxygen Species have been shown to decrease sperm motility and concentration and is associated with male infertility of unknown cause.9-32 ROS in males also damages DNA and should therefore be corrected even when assisted pregnancy is planned.31,36,40 The effect of ROS on male fertility is so well-established that many fertility specialists consider routinely testing for ROS in sub-fertile men.

Tumor Necrosis Factor-alpha (TNF-α) and Infertility

Tumor Necrosis Factor-alpha (TNF-a) is an inflammatory cytokine that stimulates free radical production by mitochondria. Don’t let the term “tumor” alarm you; everyone has TNF-α in their body. Excessive amounts of TNF-α impair fertility.

In women, high TNF-α suppresses ovarian function, increases Natural Killer cells (NK cells) and is associated with infertility. High TNF-α is also associated with recurrent spontaneous abortion.

In men, high TNF-α is associated with decreased sperm count and motility.20

Read more about inflammatory cytokines: Cytokines: A Simplified Look At Messenger Molecules

Maxi Flavone™

Broad-Spectrum Herbal Formula

Maxi Flavone is a broad-spectrum herbal antioxidant formula that affords protection from multiple ROS species, lowers TNF-alpha and is anti-inflammatory. Flavonoid-containing herbs have a synergistic effect when used in combination.41,71

Maxi Flavone supplies therapeutic doses of the most well-studied flavonoid herbs including:

I.) Pycnogenol (Pinus maritima) antioxidant and antiinflammatory effects. Please see the extensive reference list elsewhere on this website:
Grape Seed Extract and Pycnogenol

II.) Red Grape Seed (Vitus vinifera) with seeds, skin and stems which therefore contains Resveretrol. Both have potent antioxidant and anti-inflammatory effects. Resveretrol also suppresses TNF-α.72 Please see the extensive reference list elsewhere on this website: Grape Seed Extract

III.) Bilberry (Vaccinium myrtillus), the most potent of the edible berries (39), has significant antioxidant and anti-inflammatory properties 41-43,73-7. Bilberry inhibits TNF-α43 , lipid peroxidation73-74 and is an active radical scavenger of H2O242,76, superoxide and peroxynitrite.41

IV.) Green Tea (Camillia sinesis) is an antioxidant that suppresses TNF-α.44-48 It has been shown to cause regression of endometriosis in animal models.49-50

V.) Ginkgo (Ginkgo biloba) is an antioxidant that has TNF-α suppressing properties.51-57 Ginkgo raises the radical-scavenging enzymes glutathione, SOD and catalase.51-52 It has also been shown to relieve symptoms of congestive PMS.56

VI.) Milk Thistle (Silybum marianum) is an antioxidant and antiinflammatory59-63 that significantly inhibits TNF-α. 58-61,63 It has been shown to modulate immune response in vivo.60

VII.) Citrus Bioflavonoids (with hesperidin, narginen and other flavonoids) have antioxidant64-67,69, antiinflammatory58,60,64,66, and TNF-a inhibiting properties.64

Why Reproductive Immunologists Recommend Maxi Flavone™

Maxi Flavone is a state-of-the-art formulation of flavonoid-containing herbs with synergistic effects specific to fertility enhancement. Only full-spectrum extracts, not isolated flavonoids are included, thus preserving the synergistic activity of all naturally-occurring phytonutrient compounds.

Maxi Flavone contains optimal doses of the flavonoid herbs which quench Radical Oxygen Species (ROS), lower TNF-α and NK cell activity (only when excessive) and decrease excess inflammation.

In addition to the beneficial effect on fertility, these herbs also have numerous beneficial effects on overall health. Maxi Flavone™ is a potent formula providing support for immune function, circulatory health, liver detoxification mechanisms, and antioxidant pathways.

Read more about Maxi Flavone and Interleukin 6 (IL-6) here:

Using Flavones to Lower IL-6: Which is better – Luteolin / Diosmin or Maxi Flavone?

Suggested Dose for Fertility:
Women: 1 capsule per day with a meal.
Men: 1 capsule, 2 times per day with meals.

NOTE: Two capsules of Maxi Flavone™ is equivalent to 10 to 12 tablets or capsules of individual extracts taken separately, resulting in significant cost savings.

Product # F307 (60 Caps) $46.95 – Enter Quantity Desired and Click “Add To Cart” Button

(Please note: there have been rare reports of this item refusing to “add to cart” – especially for iPad / i phone users – and we are working to find the problem – if this happens to you, please just call us and we’ll be happy to take your order – 1-800-376-9288)

Yes, we can ship to Great Britain. Please contact us for details.

NOW IN STOCK AND SHIPPING!

What some Maxi Flavone users have said:

We have come across some user experiences on the fertility forums. We do not know these people, and we are not associated with them in any way except that they have purchased Maxi Flavone from us (we are the only place to obtain it) so these comments are just captures from the open internet.

From a Yahoo! Immunology Support group; You buy it online…found it by research only and I think someone once mentioned it here.  It was not prescribed or recommended by anyone but myself!  No prescription needed…all herbs and antioxidants.  Just google Maxi Flavone and Dr. Myatt and it will come up.  My cytokines were lowered in just one month!

And another Post on the Yahoo! Immunology Support group; After getting my order of MaxiFlavone (I had run out a couple of times and was too confident!) I resumed taking it and tested again , I used to test every 4 weeks and then now every 2 weeks but won’t be testing anymore this year because I have a different insurance.  Anyway, after taking and retesting again my levels ALWAYS went back to normal.  I have taken it 70-80% of my pregnancy.  I continue to take it now.  Intralipds  may often raise cytokines, everyone is different, and at that time when they spiked after intralipid or pregnancy???? I had IVIG and then MaxiFlavone  for maintenance.
I use Wobenzyme for my NK’s…which have stayed in range after IVIG almost whole pregnancy except for now…my problem was with cytokines spiking the three times I stopped taking MaxiFlavone.  Coincidence?????  I have come to the conclusion that MaxiFlavone REALLY does work!  J

A post on a Conception Support website: I have chronic inflammation from my endometriosis. I recently started a vitamin endorsed by a well known reproductive immunologist called Maxi Flavone. Within 2 days I was off my pain killers and if I miss my dose of the Maxi Flavone by even an hour the inflammation comes back, but once I take it again it disappears soon after. If there’s any sort of suspected autoimmune issues it’ll support that as well.

References

1.) Agarwal A, Allamaneni SS. Role of free radicals in female reproductive diseases and assisted reproduction. Reprod Biomed Online. 2004 Sep;9(3):338-47.
2.) Agarwal A, Gupta S, Sekhon L, Shah R. Redox considerations in female reproductive function and assisted reproduction: from molecular mechanisms to health implications. Antioxid Redox Signal.2008 Aug;10(8):1375-403.
3.) Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol. 2005 Jul 14;3:28.
4.) Agarwal A, Gupta S, Sharma R. Oxidative stress and its implications in female infertility – a clinician’s perspective. Reprod Biomed Online. 2005 Nov;11(5):641-50.
5.) Agarwal A, Gupta S, Sikka S. The role of free radicals and antioxidants in reproduction. Curr Opin Obstet Gynecol. 2006 Jun;18(3):325-32.
6.) Agarwal A, Said TM, Bedaiwy MA, Banerjee J, Alvarez JG. Oxidative stress in an assisted reproductive techniques setting. Fertil Steril. 2006 Sep;86(3):503-12. Epub 2006 Jul 24.
7.) Agarwal A, Saleh RA, Bedaiwy MA. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril. 2003 Apr;79(4):829-43.
8.) Ruder EH, Hartman TJ, Blumberg J, Goldman MB. Oxidative stress and antioxidants: exposure and impact on female fertility. Hum Reprod Update. 2008 Jul-Aug;14(4):345-57. Epub 2008 Jun 4.9.) Agarwal A, Saleh RA. Role of oxidants in male infertility: rationale, significance, and treatment. Urol Clin North Am. 2002 Nov;29(4):817-27.
10.) Aitken RJ, Buckingham D, Harkiss D. Use of a xanthine oxidase free radical generating system to investigate the cytotoxic effects of reactive oxygen species on human spermatozoa. J Reprod Fertil. 1993 Mar;97(2):441-50.
11.) Armstrong JS, Rajasekaran M, Chamulitrat W, Gatti P, Hellstrom WJ, Sikka SC. Characterization of reactive oxygen species induced effects on human spermatozoa movement and energy metabolism. Free Radic Biol Med. 1999 Apr;26(7-8):869-80.
12.) Athayde KS, Cocuzza M, Agarwal A, Krajcir N, Lucon AM, Srougi M, Hallak J. Development of normal reference values for seminal reactive oxygen species and their correlation with leukocytes and semen parameters in a fertile population. J Androl. 2007 Jul-Aug;28(4):613-20. Epub 2007 Apr 4.
13.) Aziz N, Saleh RA, Sharma RK, Lewis-Jones I, Esfandiari N, Thomas AJ Jr, Agarwal A.Novel association between sperm reactive oxygen species production, sperm morphological defects, and the sperm deformity index.Fertil Steril. 2004 Feb;81(2):349-54.
14.) Chen Q, Ng V, Mei J, Chia SE. Comparison of seminal vitamin B12, folate, reactive oxygen species and various sperm parameters between fertile and infertile males] Wei Sheng Yan Jiu. 2001 Mar;30(2):80-2. [Article in Chinese]
15.) Cocuzza M, Athayde KS, Agarwal A, Sharma R, Pagani R, Lucon AM, Srougi M, Hallak J.
Age-related increase of reactive oxygen species in neat semen in healthy fertile men. Urology. 2008 Mar;71(3):490-4.
16.) Cocuzza M, Sikka SC, Athayde KS, Agarwal A. Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysis. Int Braz J Urol. 2007 Sep-Oct;33(5):603-21.
17.) D’Agata R, Vicari E, Moncada ML, Sidoti G, Calogero AE, Fornito MC, Minacapilli G, Mongioi A, Polosa P. Generation of reactive oxygen species in subgroups of infertile men. Int J Androl. 1990 Oct;13(5):344-51.
18.) de Lamirande E, Gagnon C. Reactive oxygen species and human spermatozoa. Effects on the motility of intact spermatozoa and on sperm axonemes. Impact of reactive oxygen species on spermatozoa: a balancing act between beneficial and detrimental effects. Hum Reprod. 1995 Oct;10 Suppl 1:15-21.
19.) de Lamirande E, Gagnon C. Reactive oxygen species and human spermatozoa. I. Effects on the motility of intact spermatozoa and on sperm axonemes. J Androl. 1992 Sep-Oct;13(5):368-78.
20.) Deepinder F, Cocuzza M, Agarwal A. Should seminal oxidative stress measurement be offered routinely to men presenting for infertility evaluation? Endocr Pract. 2008 May-Jun;14(4):484-91.
21.) Ford WC, Whittington K, Williams AC. Reactive oxygen species in human sperm suspensions: production by leukocytes and the generation of NADPH to protect sperm against their effects. Int J Androl. 1997;20 Suppl 3:44-9.
22.) Fraczek M, Kurpisz M. Inflammatory mediators exert toxic effects of oxidative stress on human spermatozoa. J Androl. 2007 Mar-Apr;28(2):325-33. Epub 2006 Nov 1.
23.) Fraczek M, Szumala-Kakol A, Jedrzejczak P, Kamieniczna M, Kurpisz M.Bacteria trigger oxygen radical release and sperm lipid peroxidation in in vitro model of semen inflammation. Fertil Steril. 2007 Oct;88(4 Suppl):1076-85. Epub 2007 Mar 26.
24.) Griveau JF, Le Lannou D. Reactive oxygen species and human spermatozoa: physiology and pathology. Int J Androl. 1997 Apr;20(2):61-9. 25.) Hammadeh ME, Radwan M, Al-Hasani S, Micu R, Rosenbaum P, Lorenz M, Schmidt W. Comparison of reactive oxygen species concentration in seminal plasma and semen parameters in partners of pregnant and non-pregnant patients after IVF/ICSI. Reprod Biomed Online. 2006 Nov;13(5):696-706.
26.) Iwasaki A, Gagnon C. Formation of reactive oxygen species in spermatozoa of infertile patients. Fertil Steril. 1992 Feb;57(2):409-16.
27.) Kefer JC, Agarwal A, Sabanegh E. Role of antioxidants in the treatment of male infertility. Int J Urol. 2009 Apr 6. [Epub ahead of print]
28.) Novotný J, Oborná I, Brezinová J, Svobodová M, Hrbác J, Fingerová H. The occurrence of reactive oxygen species in the semen of males from infertile couples. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003 Dec;147(2):173-6.
29.) Oborna I, Fingerova H, Novotny J, Brezinova J, Svobodova M, Aziz N. Reactive oxygen species in human semen in relation to leukocyte contamination. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009 Mar;153(1):53-7.
30.) Pasqualotto FF, Sharma RK, Pasqualotto EB, Agarwal A. Poor semen quality and ROS-TAC scores in patients with idiopathic infertility. Urol Int. 2008;81(3):263-70. Epub 2008 Oct 16.
31.) Pasqualotto FF, Sharma RK, Nelson DR, Thomas AJ, Agarwal A. Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation. Fertil Steril. 2000 Mar;73(3):459-64.
32.) Sharma RK, Agarwal A.Role of reactive oxygen species in male infertility.Urology. 1996 Dec;48(6):835-50.
33.) Sikka SC. Relative impact of oxidative stress on male reproductive function. Curr Med Chem. 2001 Jun;8(7):851-62.
34.) Smith R, Kaune H, Parodi D, Madariaga M, Morales I, Ríos R, Castro A. [Extent of sperm DNA damage in spermatozoa from men examined for infertility. Relationship with oxidative stress] Rev Med Chil. 2007 Mar;135(3):279-86. Epub 2007 Apr 26. [Article in Spanish]
35.) Sheweita SA, Tilmisany AM, Al-Sawaf H. Mechanisms of male infertility: role of antioxidants. Curr Drug Metab. 2005 Oct;6(5):495-501.
36.) Venkatesh S, Deecaraman M, Kumar R, Shamsi MB, Dada R.Role of reactive oxygen species in the pathogenesis of mitochondrial DNA (mtDNA) mutations in male infertility.Indian J Med Res. 2009 Feb;129(2):127-37.
37.) Whittington K, Harrison SC, Williams KM, Day JL, McLaughlin EA, Hull MG, Ford WC.Reactive oxygen species (ROS) production and the outcome of diagnostic tests of sperm function. Int J Androl. 1999 Aug;22(4):236-42.
38.) Yumura Y, Iwasaki A, Saito K, Ogawa T, Hirokawa M. Effect of reactive oxygen species in semen on the pregnancy of infertile couples. Int J Urol. 2009 Feb;16(2):202-7. Epub 2008 Dec 4.
39.) Sharma RK, Pasqualotto FF, Nelson DR, Thomas AJ Jr, Agarwal A. The reactive oxygen species-total antioxidant capacity score is a new measure of oxidative stress to predict male infertility. Hum Reprod. 1999 Nov;14(11):2801-7.
40.) Zorn B, Vidmar G, Meden-Vrtovec H. Seminal reactive oxygen species as predictors of fertilization, embryo quality and pregnancy rates after conventional in vitro fertilization and intracytoplasmic sperm injection. Int J Androl. 2003 Oct;26(5):279-85.
41.) Rahman MM, Ichiyanagi T, Komiyama T, Hatano Y, Konishi T. Superoxide radical- and peroxynitrite-scavenging activity of anthocyanins; structure-activity relationship and their synergism. Free Radic Res. 2006 Sep;40(9):993-1002.
42.) Yao Y, Vieira A. Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity. Neurotoxicology. 2007 Jan;28(1):93-100. Epub 2006 Jul 31.
43.) Roy S, Khanna S, Alessio HM, Vider J, Bagchi D, Bagchi M, Sen CK. Anti-angiogenic property of edible berries. Free Radic Res. 2002 Sep;36(9):1023-31.
44.) Suganuma M, Sueoka E, Sueoka N, Okabe S, Fujiki H. Mechanisms of cancer prevention by tea polyphenols based on inhibition of TNF-alpha expression.Biofactors. 2000;13(1-4):67-72.
45.) Fujiki H, Suganuma M, Okabe S, Sueoka E, Suga K, Imai K, Nakachi K. A new concept of tumor promotion by tumor necrosis factor-alpha, and cancer preventive agents (-)-epigallocatechin gallate and green tea–a review. Cancer Detect Prev. 2000;24(1):91-9.
46.) Fujiki H, Suganuma M, Kurusu M, Okabe S, Imayoshi Y, Taniguchi S, Yoshida T.New TNF-alpha releasing inhibitors as cancer preventive agents from traditional herbal medicine and combination cancer prevention study with EGCG and sulindac or tamoxifen.Mutat Res. 2003 Feb-Mar;523-524:119-25.
47.) Rietveld A, Wiseman S. Antioxidant effects of tea: evidence from human clinical trials. J Nutr. 2003 Oct;133(10):3285S-3292S.
48.) Henning SM, Niu Y, Lee NH, Thames GD, Minutti RR, Wang H, Go VL, Heber D. Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement. Am J Clin Nutr. 2004 Dec;80(6):1558-64.
49.) Xu H, Lui WT, Chu CY, Ng PS, Wang CC, Rogers MS. Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model. Hum Reprod. 2009 Mar;24(3):608-18. Epub 2008 Dec 16.
50.) Laschke MW, Schwender C, Scheuer C, Vollmar B, Menger MD. Epigallocatechin-3-gallate inhibits estrogen-induced activation of endometrial cells in vitro and causes regression of endometriotic lesions in vivo. Hum Reprod. 2008 Oct;23(10):2308-18. Epub 2008 Jul 4.
51.) Feng X, Zhang L, Zhu H. Comparative Anticancer and Antioxidant Activities of Different Ingredients of Ginkgo biloba Extract (EGb 761). Planta Med. 2009 Mar 13. [Epub ahead of print].
52.) Kaptan ZK, Emir H, Gocmen H, Uzunkulaoglu H, Karakas A, Senes M, Samim E. Ginkgo biloba, a free oxygen radical scavenger, affects inflammatory mediators to diminish the occurrence of experimental myringosclerosis. Acta Otolaryngol. 2008 Oct 17:1-6.
53.) Bastianetto S, Zheng WH, Quirion R. The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase C.J Neurochem. 2000 Jun;74(6):2268-77.
54.) Nie ZG, Peng SY, Wang WJ. [Effects of ginkgolide B on lipopolysaccharide-induced TNFalpha production in mouse peritoneal macrophages and NF-kappaB activation in rat pleural polymorphonuclear leukocytes]. Yao Xue Xue Bao. 2004 Jun;39(6):415-8.
55.) Tian YM, Tian HJ, Zhang GY, Dai YR. Effects of Ginkgo biloba extract (EGb 761) on hydroxyl radical-induced thymocyte apoptosis and on age-related thymic atrophy and peripheral immune dysfunctions in mice. Mech Ageing Dev. 2003 Aug-Sep;124(8-9):977-83.
56.) McKenna DJ, Jones K, Hughes K. Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications. Altern Ther Health Med. 2001 Sep-Oct;7(5):70-86, 88-90.
57.) Z’Brun A. [Ginkgo–myth and reality] Praxis (Bern 1994). 1995 Jan 3;84(1):1-6.
58.) Zi X, Mukhtar H, Agarwal R. Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: inhibition of mRNA expression of an endogenous tumor promoter TNF alpha. Biochem Biophys Res Commun. 1997 Oct 9;239(1):334-9.
59.) Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB. Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis.J Immunol. 1999 Dec 15;163(12):6800-9.
60.) Johnson VJ, He Q, Osuchowski MF, Sharma RP. Physiological responses of a natural antioxidant flavonoid mixture, silymarin, in BALB/c mice: III. Silymarin inhibits T-lymphocyte function at low doses but stimulates inflammatory processes at high doses. Planta Med. 2003 Jan;69(1):44-9.
61.) Polyak SJ, Morishima C, Shuhart MC, Wang CC, Liu Y, Lee DY. Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin. Gastroenterology. 2007 May;132(5):1925-36. Epub 2007 Feb 21.
62.) Feher J, Lang I, Deak G, et al. Free radicals in tissue damage in liver diseases and therapeutic approach. Tokai J Exp Clin Med 1986;11:121–34.
63.) Toklu HZ, Tunali Akbay T, Velioglu-Ogunc A, Ercan F, Gedik N, Keyer-Uysal M, Sener G. Silymarin, the antioxidant component of Silybum marianum, prevents sepsis-induced acute lung and brain injury. J Surg Res. 2008 Apr;145(2):214-22. Epub 2007 Oct 22.
64.) Matsui T, Ito C, Itoigawa M, Okada T, Furukawa H. Effect of natsudaidain isolated from Citrus plants on TNF-alpha and cyclooxygenase-2 expression in RBL-2H3 cells. J Pharm Pharmacol. 2009 Jan;61(1):109-14.
65.) Zielinska-Przyjemska M, Ignatowicz E. Citrus fruit flavonoids influence on neutrophil apoptosis and oxidative metabolism. Phytother Res. 2008 Dec;22(12):1557-62.
66.) Benavente-García O, Castillo J. Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J Agric Food Chem. 2008 Aug 13;56(15):6185-205. Epub 2008 Jul 2.
67.) Benavente-García O, Castillo J, Alcaraz M, Vicente V, Del Río JA, Ortuño A. Beneficial action of Citrus flavonoids on multiple cancer-related biological pathways. Curr Cancer Drug Targets. 2007 Dec;7(8):795-809.
68.) Manthey JA, Grohmann K, Guthrie N. Biological properties of citrus flavonoids pertaining to cancer and inflammation. Curr Med Chem. 2001 Feb;8(2):135-53.
69.) Murakami A, Nakamura Y, Ohto Y, Yano M, Koshiba T, Koshimizu K, Tokuda H, Nishino H, Ohigashi H. Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-inflammatory polymethoxyflavonoid. Biofactors. 2000;12(1-4):187-92.
70.) González-Gallego J, Sánchez-Campos S, Tuñón MJ. Anti-inflammatory properties of dietary flavonoids. Nutr Hosp. 2007 May-Jun;22(3):287-93.
71.) Sagar SM, Yance D, Wong RK. Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 1. Curr Oncol. 2006 Feb;13(1):14-26.
72.) Manna SK, Mukhopadhyay A, Aggarwal BB. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J Immunol. 2000 Jun 15;164(12):6509-19.73.) 35.) Bao L, Yao XS, Tsi D, Yau CC, Chia CS, Nagai H, Kurihara H.Protective effects of bilberry (Vaccinium myrtillus L.) extract on KBrO3-induced kidney damage in mice.J Agric Food Chem. 2008 Jan 23;56(2):420-5. Epub 2007 Dec 20.
74.) 36.) Bao L, Yao XS, Yau CC, Tsi D, Chia CS, Nagai H, Kurihara H. Protective effects of bilberry (Vaccinium myrtillus L.) extract on restraint stress-induced liver damage in mice. J Agric Food Chem. 2008 Sep 10;56(17):7803-7. Epub 2008 Aug 9.
75.) 37.) Zafra-Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson JA, Bagchi D. Berry anthocyanins as novel antioxidants in human health and disease prevention. Mol Nutr Food Res. 2007 Jun;51(6):675-83.
76.) 38.) Milbury PE, Graf B, Curran-Celentano JM, Blumberg JB. Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells. Invest Ophthalmol Vis Sci. 2007 May;48(5):2343-9.
77.) 39.) Katsube N, Iwashita K, Tsushida T, Yamaki K, Kobori M. Induction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins. J Agric Food Chem. 2003 Jan 1;51(1):68-75