Cachexia / Catabolism

Natural Support For Unintended Weight Loss

Catabolism means “breaking down” and anabolism means “building up” body tissue. Under normal circumstances, “breaking down” and “building up” are in balance with each other, and a person maintains a consistent weight.

In weight training and weight gain, anabolism or “building up” occurs faster than catabolism, and tissue (fat or muscle) is added to the body. In catabolism, the rate of “breaking down” exceeds the “building up” phase and unintended weight loss results. Cachexia refers to malnutrition and lack of absorption that can cause catabolism.

Causes of cachexia/catabolism include chronic diseases such as tuberculosis and cancer, but catabolism can also occur without the presence of disease. In disease states it is believed that inflammatory substances produced by the body, including interleukin-1 (IL-1), IL-6, interferon gamma and tumor necrosis factor alpha (TNFa) play a role in the progression of cachexia.

Cachexia is a common problem in the elderly. Decreased production of digestive enzymes, plus changes in taste and appetite, often lead to decreased food intake. Total lower calorie consumption results in weight loss.

When the intake of protein falls below critical levels, loss of muscle tissue, including heart muscle, can occur.

When digestion and absorption are decreased, even an adequate amount of calories may not prevent weight loss. Remember, anabolism (“building up”) requires sufficient calories, sufficient protein, and normal digestion and assimilation. The above-listed inflammatory substances may prevent weight gain in spite of adequate caloric nutrition.

Diet And Lifestyle Recommendations

Diet MUST include adequate, high quality protein. This is even more important than total calories. High quality protein, especially whey protein, can be added to a “blender drink” to boost protein intake in a highly absorbable form. (See “Dr. Myatt’s Super Shake” recipe).
Exercise, especially light weight training, encourages muscle tissue to take up amino acids (protein) from the bloodstream. OVER-exercise is not recommended, but mild to moderate weight training exercise will help build muscle tissue.

Primary Support

Maxi Multi: 3 caps, 3 times per day with meals.
Protein powder: (alternate between whey and soy or use whey exclusively): 30 grams or more (2 scoops) of protein per day. This can easily (and tastily!) be taken as a “milkshake,” “hot chocolate,” or “pudding.”
Similase: 2 caps, 3 times per day with meals. (Digestive enzymes to aid assimilation)
L-glutamine: 500-1,000mg, 3 times per day with meals. L-glutamine in powdered form mixes easily with recipes. [Target dose: 3,000-5,000 mg per day].
CoQ10 (100mg): 1 cap, 2 times per day with meals.

Additional Support

Conjugated Linoleic Acid (CLA): 2000mg, 2 times per day, taken with meals.
Acetyl-L-Carnitine: 2,500mg per day, in divided doses with meals. This is especially important for vegetarians.

Dr. Myatt’s Comments (Other Considerations)

A complete physical exam is always in order for unexplained weight loss, since many curable illnesses can cause this problem.

Be sure to have a hormone profile, including thyroid and sex hormones. If you have bowel problems, a Comprehensive Digestive Stool Analysis (CDSA) is in order. Low levels of sex hormones and/or high levels of thyroid or adrenal hormones can cause weight loss. Depending on the results of these tests, your holistic physician may recommend DHEA or other hormones.

How to Calculate Protein & Calorie Requirements

Protein: Multiply your weight by 0.7. This will give you the number of grams of protein you should consume each day. Remember, total protein intake is even more important than total calorie intake, because the body cannot make protein from any other food source (fats or carbohydrates). Protein is necessary for maintenance of muscle mass (including the heart) and for an intact immune system. Excesses of protein can be stored as fat, but excesses of fat, calories, or carbohydrates (starches and sugars) cannot be converted into protein. PROTEIN INTAKE IS OF PRIMARY IMPORTANCE IN CATABOLISM.

Example: 106 pounds (put your body weight here) X 0.7= 74 grams of protein (the amount of protein a 106 pound cachexic person needs each day). Normal or overweight individuals have different protein requirements. Please refer to the “Longevity Protocol” audio tape and paper, page 134 of the Holistic Health Handbook, for precise information on calculating protein and calorie requirements in normal and overweight individuals.

Calories: Multiply your weight in pounds by 18. This will give you the number of calories that you need each day to gain weight. (This number also accounts for a mild to moderate activity level).

Example: 106 pounds (put your body weight here) x 18 = 1908 calories. (Normal or overweight individuals have different calorie requirements. Please refer to the “Longevity Protocol” audio tape and paper for information on calculating protein and calorie requirements in normal and overweight individuals.

REMEMBER: People can survive and be healthy being very lean IF they have sufficient protein to keep muscle mass, heart and the immune system functioning well.

Dr. Myatt’s Final Comment

Non-holistic physicians, upon seeing catabolism in a patient, will often recommend a liquid “milkshake-like” canned “nutritional replacement drink.” These products contain more sugar than protein (you need more protein than sugar) and many artificial additives. They are NOT your “best bet” for restoring body mass. Use your own “Super Shake” with high protein and targeted supplements instead and you can do MUCH better. Whey protein is especially valuable because it contains immune factors and cachexia can cause immune weakness.

Kick Butt

A 5-Point Program to Stop Smoking for Good

Chronic (daily) tobacco use (smoking or chewing) is one of the most health-harming habits anyone can engage in. (Daily bungee-jumping might be more harmful). And it’s not “just” lung disease: the effects of smoking cause premature aging and damage from head to toe.

In case you don’t know about the other “non-lung” problems caused by smoking, read Smoking: Just the Facts^ (The link opens in a new window). Then come back here to learn what you can do to either:

A.) help protect yourself from many of the harmful effects of tobacco use,

OR (better yet)

B.) stop smoking altogether.

Tobacco is a highly addictive substance. Some say that it is one of the most difficult drugs to quit. Here is my 5-point plan for making your “stop smoking” decision easier and surer.

1.) Decide on a “quit date.” Whether you plan on decreasing your tobacco use gradually or quitting “cold turkey,” have a “quit date” selected and stick to it.

In practice, I have observed higher success rates among those who quit “cold turkey,” but pick a plan and stick with it no matter which method you choose.

2.) Keep a “smoking triggers” diary for one week. Write down when you tend to smoke. Is it on work-break? After meals? When driving?

Whatever your “triggers” are, you’ll need to plan alternate activities. For example, if you usually smoke at work breaks, plan to take a brief walk around the building or outdoor area instead.

Nature abhors a vacuum. If you don’t have other activities planned, you’ll revert to your habitual “smoking times,” even when you don’t physically crave a cigarette.

3.) Take a high-quality multiple Vitamin/Mineral Supplement. Smoking depletes B complex vitamins, antioxidants and other nutrients. These nutrients not only protect from some of the harmful effects of smoking, but they are involved in the production of neurotransmitters.

Imbalances in neurotransmitters – aka “brain hormones” – are a common cause of cravings. Taking a high quality multiple vitamin/mineral formula helps balance these brain chemicals and reduce cravings during withdrawal from tobacco.

NOTE: You need an Optimal Dose vitamin formula (6-9 capsules per day), not a “minimal Dose one-per-day formula. Here is a chart to show you optimal doses of individual nutrients: Optimal Dose Vitamins and Minerals

4.) Neurotransmitter Testing. Smoking alters the levels of Neurotransmitters (NT’s). It may also be that alterations in NT levels contribute to initial tobacco addiction.

For example: some people smoke because it increases energy levels. Low energy, in turn, can be cause by low epinephrine (adrenaline) and norepinephrine (nor-adrenaline) NT levels. If these NT levels are low, normalizing them by natural methods can overcome the “energy rush’ offered by smoking.

Serotonin, epinephrine, norepinephrine, dopamine, GABA, PEA and histamine can all be involved in the addiction/craving cycle. A simple urine test which measures levels of these important “head hormones” can allow us to balance brain chemistry naturally and break the addictive cycle without low energy, nervousness and other symptoms many “quitters” experience.

Natural alternatives to “head meds” exist, and they can be used to balance brain chemistry once the results of your test are in.

5.) “How Bad Do You Want It”? as the Don Henley tune asks

Make sure your list of “why I want to quit” is a strong one. You’ll use this to remind yourself to stay firm when waves of cravings roll through.

It’s fine to want to quit for someone else, but be sure to have some “me” reasons on the list as well. Here are a few to get you started. Feel free to use any of those that apply to you!

Save money, improve breathing, decrease risk of heart disease, slow the aging process, live long enough to enjoy retirement (or the grandkids), set a good example for the grandkids (or your own children), not smell like stale smoke all the time, be free of addiction, have more energy, move with greater ease.

By following this 5-point program, anyone who really wants to quit can do so. I’ve got hundreds of successful “quitters” in my practice, a testimony to the success of this program and the power of genuine motivation.

Potassium Citrate Powder

100% Pure Food Grade Tri-Potassium Citrate Powder (Anhydrous Tripotassium Citrate)

Potassium is an alkalinizing mineral that is typically deficient in the American diet. The primary source of dietary potassium is from fruits and vegetables.

Mild metabolic acidosis (MMA) results from low intakes of alkaline fruits and vegetables and high intakes of grain and protein foods. This MMA can cause the gradual leaching of minerals from bone,leading to osteoporosis. MMA and/or lack of urinary citrate is also a metabolic factor in the formation of kidney stones.

Potassium citrate serves as a source of both potassium and citrate and has been found useful for:

- increasing bone mineral density and improving bone architecture (1-4)
- decreasing the formation of kidney stones by up to 93% (3-11)
- alkalinizing the body and reversing mild metabolic acidosis (7)

Potassium Citrate Powder is used to treat kidney damage and specifically, metabolic acidosis which is where the blood is more acidic than normal. Potassium Citrate Powder may be used to help pass kidney and bladder stones through the body easily and less painfully, as it causes the stones to break down while passing through the body.

Some people take Potassium Citrate Powder just to reduce the amount of acid in the urine or increase the pH levels- that is, to “alkalinize.”

Suggested Use: Take as directed by your health care professional. DO NOT take more than recommended.

Doses in the studies range from 1 mEq/kg daily in children (10) up to 80 mEq (3120milligrams) daily total for adults. (7-8)
Eight grams (8g) of potassium citrate contains approximately 3,000mg potassium. This amount can be found in 1 and 1/4 tsp.

It is best taken in divided doses; that is, divided into two or three doses daily.

To use: Carefully measure and mix the desired amount of potassium citrate in a glass of warm water, mix well, and drink. Can be mixed with sugar-free flavored beverages – we recommend ZipFizz for a healthy “sports drink.”

References:

1.) Jehle S, Hulter HN, Krapf R. Effect of Potassium Citrate on Bone Density,
Microarchitecture, and Fracture Risk in Healthy Older Adults without Osteoporosis: A Randomized Controlled Trial. J Clin Endocrinol Metab. 2012 Nov 15. [Epub ahead of print]
2.) Harrington M, Cashman KD. High salt intake appears to increase bone resorption in postmenopausal women but high potassium intake ameliorates this adverse effect. Nutr Rev. 2003 May;61(5 Pt 1):179-83.
3.) Jehle S, Zanetti A, Muser J, Hulter HN, Krapf R. Partial neutralization of the acidogenic Western diet with potassium citrate increases bone mass in postmenopausal women with osteopenia. J Am Soc Nephrol. 2006
Nov;17(11):3213-22. Epub 2006 Oct 11.
4.) Vescini F, Buffa A, La Manna G, Ciavatti A, Rizzoli E, Bottura A, Stefoni S, Caudarella R. Long-term potassium citrate therapy and bone mineral density in idiopathic calcium stone formers. J Endocrinol Invest. 2005 Mar;28(3):218-22.
5.) Lojanapiwat B, Tanthanuch M, Pripathanont C, Ratchanon S, Srinualnad S, Taweemonkongsap T, Kanyok S, Lammongkolkul S. Alkaline citrate reduces stone recurrence and regrowth after shockwave lithotripsy and percutaneous nephrolithotomy. Int Braz J Urol. 2011 Sep-Oct;37(5):611-6.
6.) Pak CY, Peterson RD, Poindexter J. Prevention of spinal bone loss by potassium citrate in cases of calcium urolithiasis. J Urol. 2002 Jul;168(1):31-4.
7.) Pak CY, Fuller C. Idiopathic hypocitraturic calcium-oxalate nephrolithiasis successfully treated with potassium citrate. Ann Intern Med. 1986 Jan;104(1):33-7.
8.) Preminger GM, Sakhaee K, Skurla C, Pak CY. Prevention of recurrent calcium stone formation with potassium citrate therapy in patients with distal renal tubular acidosis. J Urol. 1985 Jul;134(1):20-3.
9.) Robinson MR, Leitao VA, Haleblian GE, Scales CD Jr, Chandrashekar A, Pierre SA, Preminger GM. Impact of long-term potassium citrate therapy on urinary profiles and recurrent stone formation. J Urol. 2009 Mar;181(3):1145-50. Epub 2009 Jan 18.
10.) Sarica K, Erturhan S, Yurtseven C, Yagci F. Effect of potassium citrate therapy on stone recurrence and regrowth after extracorporeal shockwave lithotripsy in children. J Endourol. 2006 Nov;20(11):875-9.
11.) Soygür T, Akbay A, Küpeli S. Effect of potassium citrate therapy on stone recurrence and residual fragments after shockwave lithotripsy in lower caliceal calcium oxalate urolithiasis: a randomized controlled trial. J Endourol. 2002 Apr;16(3):149-52.

Flu Vaccinations:

A Shot in The Dark?

When I was 8, one of my friend’s dad died suddenly, at the ripe old age of 35, of the flu. Not cancer, not a heart attack, not a car wreck — the flu.

One day he was sick in bed with fever, chills, and headache. The next day he saw the family doctor who prescribed an antibiotic (which is worthless for the flu). He had an anaphylactic reaction (severe allergic reaction) to the antibiotic and died that same day. Even at the tender age of 8, it just didn’t seem right for someone to die of such a “garden variety” illness. But he did, and people still do.

As old-fashioned a disease as “the flu” (influenza) is, 24.7 million people in the US contract the flu each year and over 100,000 of these cases require hospitalization. An average of 41,400 people die from complications of the flu in the US alone every year. Notice I said “complications.” People don’t die of the flu directly. They die of pneumonia or other “flu-related” diseases.1, 2 But don’t expect a flu shot to protect you. That’s because the effectiveness of the “flu shot” is in serious question.

Why The Flu Vaccine is a Bust

The flu is caused by over 200 different viruses and infective agents; colds are caused by over 700 viruses. Vaccinations against the flu protect against only THREE influenza A and B — that’s right — three of the 200 known A & B viruses, and A and B influenza viruses comprise only a small fraction of all causes of the flu.

Influenza vaccines are designed to protect against 3 Influenza viruses A & B (solid pink piece of the pie graph)

Influenza vaccines are designed to protect against 3 Influenza viruses A & B (solid pink piece of the pie graph). Graph courtesy of the British Medical Journal.

So, the flu vaccine protects from only a small percentage of the known causes of flu and flu vaccines may be effective as little as 39% (some studies show 0%) of the time in healthy adults.3 According to the FDA, “The shot doesn’t do as well at preventing flu in older adults and people with certain medical problems.” 4

Great. Flu vaccines only protect against a small number of viruses, are effective 39% or less of the time and work even less well in people who need it most, the elderly and immune-weakened folks. I’d say the flu vaccine is a real shot in the dark. Worse than ineffective or benign, the influenza vaccine is still preserved with thimerosol (mercury), a known neurotoxin. (Mercury-free vaccines exist but you won’t get it unless you specifically request it).

Of course, the flu isn’t the only malady we are more susceptible to in Winter months. Plain ol’ colds and sinus and respiratory infections also increase in the Winter, not because of cold temperatures directly but because viruses spread more easily in cold, dry air.

If the thought of getting sick, or possibly really sick, this Winter doesn’t inspire you, and if feel like I do —- totally underwhelmed by the effectiveness of the flu vaccine — what can you do?

Fortunately, Mother Nature has more immune-boosting strategies than modern medicine will EVER think of. Here are 4 simple, proven recommendations for keeping yourself “bullet proof” against not only the flu, but colds, sinus infections, pneumonia and all manner of Winter-time maladies.

How to Make Yourself Flu-Proof: “Winterize” Your Immune System in Four Easy Steps

1.) Eat an Immune-Boosting Diet. The two major dietary causes of immune suppression are sugar intake and food allergies.

I.) Dietary sugar. Sugar suppresses the activity of white blood cells (neutrophils) — an important part of the immune system — for up to 5 hours. Even fruit juice contains enough sugar to cause this immune-suppressing effect. Sugars which cause immune suppression include glucose, fructose, sucrose, honey, and orange juice.6,7,8 Although original studies showed an immune suppressing effect at 100 grams of sugar other studies have shown that even much lower intakes of dietary sugar have immune suppressing effects. 9,10. The USDA and the Center for Science in Public Interest (CSPI) agree that 40 grams of sugar is an acceptable daily limit.

Imagine a “healthy” (not!) day of eating that can actually keep immunity suppressed for the entire day.

Breakfast: glass of orange juice (1 cup has 21 grams of sugar), oatmeal with raisins (2 TBS. has 20 grams of sugar), 1 tsp. of sugar (4 grams of sugar) and lowfat milk (1 cup has 13 grams of sugar). That’s a whopping 58 grams of sugar just for breakfast! Expect a suppressed immune system for the next 5 hours.

Snack: Nonfat fruit-variety yogurt (1 cup has 47 grams of sugar) Immune suppression for up to 5 hours.

Lunch: Subway Chicken Teriyaki Sanwich (6 grams of sugar) with 2 oz. fat-free French dressing (12 grams sugar) and 1 oatmeal raisin cookie for desert (16 grams of sugar) [32 grams total]. Immune system still suppressed from breakfast and snack.

Dinner: green salad with 2 TBS. fat-free french dressing (6 grams), 1 serving Weight Watcher’s chicken enchiladas (33 grams) with 2 TBS fat-free yogurt topping (2 grams) [41 grams total] Immune suppression until bedtime.

Dessert: 1/2 cup Breyer’s no sugar added vanilla ice cream (only 4 grams), but it’s the “cherry” on the immune-suppression-day cake!

There you have it. “A day in the life” of someone who thinks they are eating fairly well, with more than enough sugar to cause all-day immune suppression. Notice that fruit juice and flavored yogurt are major offenders.

Avoiding sugar is the most important dietary step you can take to strengthen your immune system. Period.

II.) Food allergies. Food allergies weaken the immune system. White blood cells and other aspects of immunity get “distracted” taking care of internal annoyances (allergens) instead of protecting against outside “bugs” like the flu virus. Check out the symptoms of food allergy to see if this might be a problem for you. Check Food Allergy Symptoms Here

2.) Practice simple home and hygiene techniques.

I.) Wash your hands frequently. Flu and cold viruses can survive on surfaces, including hands, for hours. Every time you touch a doorknob or anything touched by another, you can pick up a virus. And don’t rub your eyes or face, thereby transmitting the virus to yourself from unwashed hands.

II.) Cover your mouth and nose — preferably with a tissue — when you sneeze or cough. Remember, flu and cold viruses are transmitted primarily through airborne droplets.

III.) Take the day off! If you’re suffering from a cold, do co-workers and friends a favor and quarantine yourself at home until you’re no longer sneezing and hacking. Of course, if you’ve got a bona fide case of the flu, you WILL be taking the day off. Flu symptoms are almost always severe enough to cause prostration.

IV.) Keep your house humid. Indoor fountains (even the little table-top varieties), humidifiers and live plants all help keep indoor Winter air moist. Viruses spread more slowly in higher humidity because airborne water droplets “grab” the viruses and pull them out of circulation. In dry air, viruses are left to float around from one sneezing, coughing host to another.5

3.) Strengthen your immune system with supplements.

I.) Take an optimal potency vitamin/mineral supplement every day. If you only take one supplement to strengthen your immune system, it should be a good multiple formula. Studies have shown that seniors who take a multiple have stronger immune systems and are less likely to get a respiratory tract infection or the flu.11,12,13 A deficiency of any single vitamin, mineral or trace mineral can lead to weakened immunity. 12-23 Improved nutritional status by supplementation can also improve the body’s response to vaccinations. 24

Notice I said optimal potency, not “minimal.” Studies have also shown that a one-per-day formula does virtually nothing to improve immunity. That’s because you can’t fit enough nutrients into one tablet or capsule to do anything but prevent severe deficiency diseases (like just enough vitamin C to prevent scurvy but not enough to strengthen the immune system). In the nutritional industry, we call that “pixie dust.” An optimal-potency multi vitamin will require at least 6 caps per day (in divided doses). My Maxi Multi recommendation is 9 caps per day, which also includes a full dose of calcium and magnesium (which take up a lot of space in a capsule).

Here are the nutrients of particular immune-enhancing importance, and they should all be found in a good multiple nutrient formula.

vitamin C – people with daily intakes of 500-1,000mg per day are less likely to catch colds, respiratory tract infections and pneumonia. Vitamin C also shortens the duration and severity of these infections.25-29,45
vitamin E – 200IU or more per day reduces the rate of common colds and upper respiratory tract infections 30,31 and increases resistance to influenza in seniors.18, 32-35,44
beta carotene – seniors with a high plasma beta-carotene concentration have a lower occurrence of acute respiratory infections.36
vitamin A – needed to maintain normal “barrier” function of skin and mucous membranes, thereby preventing entry of viruses. Normal levels improve immunity and disease resistance.14,23,29,37-38
vitamin D – Improves immunity and may enhance response to vaccinations.14,23,37,39
zinc – normal zinc status lowers the risk of pneumonia by nearly 50% 40 and decreases the incidence, duration and severity of upper respiratory infections and pneumonia.18,38,41,45 Improved zinc status also enhances the body’s response to vaccinations.11,29
selenium – Decreases the risk of respiratory tract infections. Improved selenium status also enhances the body’s response to vaccinations.11,18,35,42-43

If you are not getting these target doses in your multiple vitamin, then add them separately OR switch to a better multiple vitamin/mineral formula. You can take a lot of “separate stuff” to achieve immune-boosting “target doses” of nutrients, but why would you want to work that hard?

SHAMELESS PITCH HERE: my own Maxi Multi’s contain target doses of all these immune-boosting nutrients. Check to see how your multiple stacks up: Optimal Doses of Vitamins and Minerals for Good Health (scroll to the vitamin and mineral charts toward the bottom of the page)

II.) Supplement with additional immune-boosting herbs. For additional protection, add an immune-enhancing formula throughout the colder months (recommended November through April). There are literally hundreds of herbs that can be used to strengthen the immune system. Some work better — and some work MUCH better — than others.

I’ve put together my own formula of the most “tried and true” (and proven) immune enhancing herbs including Echinacea, astragalus, medicinal mushrooms (Maitake, Shiitake, Reishi), Ligustrum, Goldenseal and Garlic. Learn more about my Immune Support formula here:

I Guarantee You Won’t Get The Flu This Winter

I’m so confident that Immune Support formula, when used in combination with an optimal potency multiple like Maxi Multi, will help you avoid the flu that I offer a “guaranteed no flu this Winter” money-back guarantee. How confident is that?! Did your local doctor promise if you got a flu shot you wouldn’t get the flu or your money back? (Hahahaha….) See my “No Flu for You” Guarantee here

And for Goodness sakes, don’t wait until you feel fever and chills coming on to start taking supplements or eating better (although even late in the game, studies show you can shorten the severity and duration of a winter infection). Prevention is surer and safer than cure, and looks to me to be surer and safer than the flu vaccine, too!

In Health,

Dr. Myatt

References

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Molinari NA, Ortega-Sanchez IR, Messonnier ML, Thompson WW, Wortley PM, Weintraub E, Bridges CB. The annual impact of seasonal influenza in the US: measuring disease burden and costs. Vaccine. 2007 Jun 28;25(27):5086-96. Epub 2007 Apr 20.
Demicheli V, Rivetti D, Deeks JJ, Jefferson TO. Vaccines for preventing influenza in healthy adults. Cochrane Database Syst Rev 2004;3: CD001269.
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Lowen AC, Mubareka S, Steel J, Palese P (2007) Influenza Virus Transmission Is Dependent on Relative Humidity and Temperature. PLoS Pathog 3(10): e151. doi:10.1371/journal.ppat.0030151
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Ringsdorf WM jr, Cheraskin E and Ramsey RR jr. Sucrose, Neutrophilic Phagocytosis, and Resistance to Disease. Dent Surv 1976; 52 (12): 46-48
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Beck MA. Nutritionally induced oxidative stress: effect on viral disease. Am J Clin Nutr. 2000 Jun;71(6 Suppl):1676S-81S.
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Sasazuki S, Sasaki S, Tsubono Y, Okubo S, Hayashi M, Tsugane S.Effect of vitamin C on common cold: randomized controlled trial.Eur J Clin Nutr. 2006 Jan;60(1):9-17.
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Carr AB, Einstein R, Lai LY, Martin NG, Starmer GA. Vitamin C and the common cold: using identical twins as controls. Med J Aust. 1981 Oct 17;2(8):411-2.
Anderson TW, Beaton GH, Corey P, Spero L. Winter illness and vitamin C: the effect of relatively low doses. Can Med Assoc J. 1975 Apr 5;112(7):823-6.
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Meydani SN, Han SN, Hamer DH. Vitamin E and respiratory infection in the elderly. Ann N Y Acad Sci. 2004 Dec;1031:214-22.
Meydani SN, Leka LS, Fine BC, Dallal GE, Keusch GT, Singh MF, Hamer DH. Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial. JAMA. 2004 Aug 18;292(7):828-36.
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Beck MA. Selenium and vitamin E status: impact on viral pathogenicity. J Nutr. 2007 May;137(5):1338-40.
van der Horst-Graat JM, Kok FJ, Schouten EG. Plasma carotenoid concentrations in relation to acute respiratory infections in elderly people. Br J Nutr. 2004 Jul;92(1):113-8
Mora JR, Iwata M, von Andrian UH. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol. 2008 Aug 8. [Epub ahead of print]
Molina EL, Patel JA. A to Z: vitamin A and zinc, the miracle duo.Indian J Pediatr. 1996 Jul-Aug;63(4):427-31.
Hayes CE, Nashold FE, Spach KM, Pedersen LB.The immunological functions of the vitamin D endocrine system. Cell Mol Biol (Noisy-le-grand). 2003 Mar;49(2):277-300.
Meydani SN, Barnett JB, Dallal GE, Fine BC, Jacques PF, Leka LS, Hamer DH. Serum zinc and pneumonia in nursing home elderly.Am J Clin Nutr. 2007 Oct;86(4):1167-73.
Wintergerst ES, Maggini S, Hornig DH. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab. 2006;50(2):85-94. Epub 2005 Dec 21.
Beck MA. Antioxidants and viral infections: host immune response and viral pathogenicity. J Am Coll Nutr. 2001 Oct;20(5 Suppl):384S-388S; discussion 396S-397S.
Beck MA. Selenium and host defence towards viruses. Proc Nutr Soc. 1999 Aug;58(3):707-11.
Burton A. Fewer colds with increased vitamin E intake. Lancet Infect Dis. 2004 Oct;4(10):600.
Wintergerst ES, Maggini S, Hornig DH. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab. 2006;50(2):85-94. Epub 2005 Dec 21.

About Dr. Dana

Dr. Dana Myatt

Naturopathic Medical Doctor

See Dr. Myatt’s Curriculum Vitae and Credentials

Verify Dr. Dana Myatt’s Medical License

Dana Myatt, N.M.D., is a naturopathic medical doctor, medical educator, anti-aging and longevity specialist and author. She is Founder and Chief Medical Officer of The Wellness Club, a natural health education service and nutritional supplement company founded in 1994.

Dr. Myatt has seen a lot of “firsts” in her thirty-four year medical career.

She was the first naturopathic physician on staff at the A.R.E. Clinic, one of the country’s first and oldest holistic medical centers, where she did her Residency and later served as the Director of Medical Residencies, supervising the training of doctors, nurses and medical students in holistic healing techniques. She also served as the Admissions Evaluation Physician for the A.R.E. Clinic Neurological Improvement Program.

She became the first naturopathic doctor on staff at the Scottsdale Holistic Medical Group.

Dr. Myatt guest lectures nationwide at both medical and lay conferences. She has presented at Bastyr College, National College of Naturopathic Medicine, Southwest College, Saint Joseph’s Medical Center, St. Mary Pia Cancer Center, and Eastern Virginia College of Medicine to name a few. Dr. Myatt was Professor of Holistic Health at Atlantic University where she developed the Holistic Health Correspondence Curriculum for the University.

Her book “A Physician’s Diary : Cured Cases With Edgar Cayce and Other Natural Remedies” was chosen as a sponsoring member benefit for the Association for Research and Enlightenment. Her forthcoming book, The Keto Zone Diet, will be the first book to explain the use of ketosis (a natural metabolic process) for fast fat loss and health restoration.

Dr. Myatt was one of the first physicians to practice “telemedicine” (medicine by telephone), back when “they” said it couldn’t be done. Her expertise in conventional, complementary and natural medicine is available by telephone for patients and their physicians world-wide through Consultations with Dr. Myatt

Some Frequently Asked Questions about Dr. Myatt

Dr. Dana Myatt

Naturopathic Medical Doctor

See Dr. Myatt’s Curriculum Vitae and Credentials

Verify Dr. Dana Myatt’s Medical License

Dr. Myatt has seen a lot of “firsts” in her twenty-one year medical career.

She was the first naturopathic physician on staff at the A.R.E. Clinic, one of the country’s first and oldest holistic medical centers, where she did her Residency and later served as the Director of Medical Residencies, supervising the training of doctors, nurses and medical students in holistic healing techniques. She was also the first naturopathic doctor on staff at the Scottsdale Holistic Medical Group.

Some Frequently Asked Questions about Dr. Myatt

CANCER PREVENTION

Natural Strategies To Help Avoid Cancer

What is Cancer?
The word “cancer” is a general term used to describe body cells that grow uncontrollably and often invade other body tissue. Benign tumors are also body cells that multiply, but they do not grow uncontrollably and invade other parts of the body. Cancer can begin in virtually any part of the body. The most common locations for cancer are the lungs, colon, breast, and prostate.

How does Cancer start?
Scientists believe that cancer starts as a single cell with altered chromosomes. Chromosomes are the “brain” inside each cell in the body. Chromosomes tell the cell how to behave.

In cancer cells, abnormal chromosomes give rise to abnormal cell behavior. Such abnormal behavior includes rapid multiplication of cells. Unlike normal cells, cancer cells do not stop growing when they reach a particular number. Instead, they continue to multiply, pushing on vital organs, robbing the “host” of nutrients, and spreading to other parts of the body by way of the lymphatic or blood-vascular system. (A process called “metastasis”).

What Causes Cancer?
Altered chromosomes inside the cell are ultimately thought to be responsible for abnormal cell behavior. But what causes chromosomes to become altered?

A number of factors are known to alter chromosomes. Some of these alterations may be pre-programmed into a cell; what we would call “genetic.” A person may be born with such abnormal chromosomes.

Other factors that are known to damage chromosomes and initiate cancer are known as carcinogens. These appear to be a far more common cause of cancer. Carcinogenic substances include ionizing radiation, smoke, and a wide variety of chemicals. Chronic irritation of any body tissue can also cause a cell to become cancerous.

Cancer and the Immune System
Scientists have demonstrated that a normal body produces approximately 300 or more cancerous cells per day. So why doesn’t everyone develop cancer? The answer lies in the immune system, a portion of the body that is designed to protect us from foreign “invasion.” In a body with a healthy immune system, cancer cells are recognized and destroyed. This process occurs inside everyone, all the time, every day. When the immune system is “compromised’ for any reason – for example, from nutritional deficiencies, cigarette smoking, or excessive physical or emotional stress – it may fail to identify cancerous cells. Once a cancerous cell begins to multiply, it becomes more difficult for the immune system to contain it. (Think of a wild fire. Very early, it is easy to put out. Let it “grow” for a while, and it becomes more dangerous).

Diagnosis of Cancer
There is no early blood or other tests that will tell us when an aberrant cell has escaped immune system recognition. In fact, our current diagnosis of cancer usually relies on a “mass,” or noticeable tumor, being present. Mammography, a low dose X-ray picture taken of the female breast, is an example of an early detection method. Though often touted as “prevention,” it is not. Diagnostic test are a means of early detection of cancer. They are NOT preventive measures.

The “War on Cancer”
President Nixon signed a bill on December 23, 1971, declaring an all-out “war” on cancer. This bill opened a floodgate of federal funding to research a cure for cancer. Since the signing of this bill, tens of billions of dollars of federal money, and additional private sector money, have been spent on this “war on cancer.”

Don’t let anyone fool you: it’s a “war” we’re losing. Since the signing of this bill, the death rate from cancer has risen. Some people will tell you these statistics are inaccurate because people are living longer, but this, too, is a falsehood. These numbers are age adjusted.

Common cancers, such as lung cancer, are increasingly common. Prostate and brain cancers and non-Hodgkin’s lymphoma are beginning to rise in the general population. So are a number of other types of cancer.

Conventional Treatment of Cancer
Like the stories that suggest that we are winning the “war on cancer,” conventional treatment improvements are a myth. There has been little significant advancement in the treatment of cancer in the past twenty years.

What has improved is our ability to detect cancer earlier, when it is still curable by surgery alone. Radiation and chemotherapy can provide a margin of additional “time” in a few types of cancer, but often at the expense of quality of life.

Surgery still remains one of the best conventional treatments for cancer, and then, it is most effective when the cancer is detected early. Surgery is also more effective when the immune system is otherwise strong and healthy.

Don’t misunderstand me. There are some advances in survival times with the use of certain drugs. For example, the anti-estrogen drug Tamoxifen improves survival times in post menopausal women with hormone-responsive breast cancer. Of course, if these women were “stage I” or “stage II’ when their cancer was removed, the chance of recurrence of cancer is very low anyway. Again, this is an indication that early detection and surgical removal remains one of our most effective conventional treatments. Certain nutritional supplements should sometimes be avoided during chemotherapy because they can reduce the effectiveness of the drugs, but most supplements actually minimize negative side-effects of chemotherapy and radiation. And there are some types of cancers that, although present in a body, should probably be left alone because they are unlikely to spread.

All of these questions need to be answered with the assistance of an holistic physician who can help you determine the best course of action to take and will work with you to sort out the legitimate treatments from the “hype.” There is no room for guesswork and inexperience once a diagnosis of cancer has been made. Please consider obtaining a consultation with Dr. Myatt.

Prevention is the Best “Cure”
Modern medical science may not know much more about treating cancer than it did twenty years ago, but we do know a lot more about prevention. At this point in medical history, it’s fair to say that prevention of cancer is a surer and safer bet than cure.

DIET AND LIFESTYLE RECOMMENDATIONS

Maintain a normal weight. Excess body fat is associated with a number of cancers, including postmenopausal breast cancer and prostate cancer.
Eat a diet rich in antioxidant nutrient foods (fruits and vegetables). Include “Super Foods” lavishly. Use soy and soy products if tolerated. Buy organic produce whenever possible.
Do not smoke. Limit alcohol consumption.
Drink pure water, not tap water. Chlorine byproducts are can cause urinary tract and other cancers. Other contaminants in water have unknown effects but many are believed to relate to cancer.
Exercise regularly. Many types of cancers (ovarian, breast, prostate, colon) occur far less often (up to 50% less) in people who engage in regular physical activity. [Ref.: N. Eng. J. Med. 338:94,1998]
Practice “Emotional hygiene.” Emotional distress (“stress”) suppresses the immune system and may make a person more susceptible to cancer and other diseases. Conversely, optimism is associated with improved immunity in a number of studies. Watch The Body/Mind Connection video to learn exactly how this occurs.

PRIMARY SUPPORT:

Maxi Multi: 3 caps, 3 times per day with meals. Optimal (not minimal) doses of all nutrients are important in preventing cancer, since a single micronutrient deficiency can cause immune system weakness. Antioxidants (A, C, carotene and selenium), and vitamin D are especially important.
Maxi Greens: 3 caps, 3 times daily with meals for complete phytonutrient coverage.
Omega 3 fatty acids:
Flax seed meal, 2 teaspoons per day with food
OR
Flax seed capsules: 2-4 caps, 3 times per day (target dose range: 6-12 caps per day)
OR
Flax seed oil: 1-2 tablespoons per day
OR
Max EPA (Omega-3 rich fish oil): 1-2 caps, 3 times per day with meals (target dose: 3-6 caps per day).

ADDITIONAL SUPPORT

Diindolymethane (DIM): 2 caps, 2 times per day.
Turmeric: 1 caps, 2-3 times per day with meals.
Melatonin: 3-5mg at bedtime

References

Body Weight (BMI) and Cancer

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Super Foods

1.) Khan N, Afaq F, Mukhtar H. Cancer Chemoprevention Through Dietary Antioxidants: Progress and Promise. Antioxid Redox Signal. 2007 Dec 21 [Epub ahead of print].
2.) Moreno DA, López-Berenguer C, García-Viguera C. Effects of stir-fry cooking with different edible oils on the phytochemical composition of broccoli. J Food Sci. 2007 Jan;72(1):S064-8.
3.) Cohen JH, Kristal AR, Stanford JL. Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst 2000;92(1):61–8.
4.) Cohen JH, Kristal AR, Stanford JL. Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst 2000;92(1):61–8.
5.) Kune GA. Eating fish protects against some cancers: epidemiological and experimental evidence for a hypothesis. J Nutr Med 1990;1:139–44 [review].
6.) Rose DP, Connolley JM. Omega-3 fatty acids as cancer chemopreventive agents. Pharmacol Ther 1999;83:217–44.
7.) Demark-Wahnefried W, Price DT, Polascik TJ, et al. Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. Urology2001;58:47–52.
8.) Davis JN, Singh B, Bhuiyan M, Sarkar FH. Genistein-induced upregulation of p21WAF1, downregulation of cyclin B, and induction of apoptosis in prostate cancer cells. Nutr Cancer 1998;32:123–31.
9.) Barnes S, Peterson TG, Coward L. Rationale for the use of genistein-containing soy matrices in chemoprevention trials for breast and prostate cancer. J Cell Biochem Suppl 1995;22:181–7.
10.) Jacobsen BK, Knutsen SF, Fraser GE. Does high soy milk intake reduce prostate cancer incidence? The Adventist Health Study (United States). Cancer Causes Control 1998;9:553–7.
11.) Geller J, Sionit L, Partido C, et al. Genistein inhibits the growth of human-patient BPH and prostate cancer in histoculture. Prostate 1998;34:75–9.

Smoking, Alcohol and Cancer Risk

1.) Kaufman EL, Jacobson JS, Hershman DL, Desai M, Neugut AI. Effect of breast cancer radiotherapy and cigarette smoking on risk of second primary lung cancer. J Clin Oncol. 2008 Jan 20;26(3):392-8.
2.) Park SM, Lim MK, Jung KW, Shin SA, Yoo KY, Yun YH, Huh BY. Prediagnosis smoking, obesity, insulin resistance, and second primary cancer risk in male cancer survivors: National Health Insurance Corporation Study. J Clin Oncol. 2007 Oct 20;25(30):4835-43.
3.) Koskinen WJ, Brøndbo K, Mellin Dahlstrand H, Luostarinen T, Hakulinen T, Leivo I, Molijn A, Quint WG, Røysland T, Munck-Wikland E, Mäkitie AA, Pyykkö I, Dillner J, Vaheri A,
Aaltonen LM. Alcohol, smoking and human papillomavirus in laryngeal carcinoma: a Nordic prospective multicenter study. J Cancer Res Clin Oncol. 2007 Sep;133(9):673-8. Epub 2007 May 8.
4.) Muwonge R, Ramadas K, Sankila R, Thara S, Thomas G, Vinoda J, Sankaranarayanan R. Role of tobacco smoking, chewing and alcohol drinking in the risk of oral cancer in Trivandrum, India: A nested case-control design using incident cancer cases. Oral Oncol. 2007 Oct 12
5.) Chen CH, Shun CT, Huang KH, Huang CY, Tsai YC, Yu HJ, Pu YS. Stopping smoking might reduce tumour recurrence in nonmuscle-invasive bladder cancer. BJU Int. 2007 Aug;100(2):281-6; discussion 286. Epub 2007 Apr 5.
6.) Rieck G, Fiander A.The effect of lifestyle factors on gynaecological cancer. Best Pract Res Clin Obstet Gynaecol. 2006 Apr;20(2):227-51.
7.) Ford MB, Sigurdson AJ, Petrulis ES, Ng CS, Kemp B, Cooksley C, McNeese M, Selwyn BJ, Spitz MR, Bondy ML.Effects of smoking and radiotherapy on lung carcinoma in breast carcinoma survivors. Cancer. 2003 Oct 1;98(7):1457-64.
8.) van Leeuwen FE, Klokman WJ, Stovall M, Hagenbeek A, van den Belt-Dusebout AW, Noyon R, Boice JD Jr, Burgers JM, Somers R. Roles of radiotherapy and smoking in lung cancer following Hodgkin’s disease. J Natl Cancer Inst. 1995 Oct 18;87(20):1530-7.
9.) Neugut AI, Murray T, Santos J, Amols H, Hayes MK, Flannery JT, Robinson E. Increased risk of lung cancer after breast cancer radiation therapy in cigarette smokers. Cancer. 1994 Mar
15;73(6):1541-3.
10.) Day GL, Blot WJ, Shore RE, McLaughlin JK, Austin DF, Greenberg RS, Liff JM, Preston-Martin S, Sarkar S, Schoenberg JB, et al. Second cancers following oral and pharyngeal cancers: role of tobacco and alcohol. J Natl Cancer Inst. 1994 Jan 19;86(2):131-7.
11.) Day GL, Shore RE, Blot WJ, McLaughlin JK, Austin DF, Greenberg RS, Liff JM, Preston-Martin S, Sarkar S, Schoenberg JB, et al. Dietary factors and second primary cancers: a follow-up of oral and pharyngeal cancer patients. Nutr Cancer. 1994;21(3):223-32.

Drinking Water and Cancer Risk

1.) Richardson SD, Plewa MJ, Wagner ED, Schoeny R, Demarini DM. Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research. Mutat Res. 2007 Nov-Dec;636(1-3):178-242. Epub 2007 Sep 12.
2.) Kasim K, Levallois P, Johnson KC, Abdous B, Auger P; Canadian Cancer Registries Epidemiology Research Group. Chlorination disinfection by-products in drinking water and the risk of adult leukemia in Canada. Am J Epidemiol. 2006 Jan 15;163(2):116-26. Epub 2005 Nov 30.
3.) Do MT, Birkett NJ, Johnson KC, Krewski D, Villeneuve P; Canadian Cancer Registries Epidemiology Research Group. Chlorination disinfection by-products and pancreatic cancer risk.
Environ Health Perspect. 2005 Apr;113(4):418-24.
4.) Cancer Causes Control. 1996 Nov;7(6):596-604. Drinking water source and chlorination byproducts in Iowa. III. Risk of brain cancer. Am J Epidemiol. 1999 Sep 15;150(6):552-60.
5.) Wigle DT. Safe drinking water: a public health challenge. Chronic Dis Can. 1998;19(3):103-7. Review.
6.) Cantor KP, Lynch CF, Hildesheim ME, Dosemeci M, Lubin J, Alavanja M, Craun G.Drinking water source and chlorination byproducts. I. Risk of bladder cancer. Epidemiology. 1998 Jan;9(1):21-8.
7.) King WD, Marrett LD. Case-control study of bladder cancer and chlorination by-products in treated water (Ontario, Canada). Cancer Causes Control. 1996 Nov;7(6):596-604.

Exercise and Cancer

1.) Valenti M, Porzio G, Aielli F, Verna L, Cannita K, Manno R, Masedu F, Marchetti P, Ficorella C.Physical exercise and quality of life in breast cancer survivors. Int J Med Sci. 2008 Jan 15;5(1):24-8.
2.) Greenspan SL. Approach to the prostate cancer patient with bone disease. J Clin Endocrinol Metab. 2008 Jan;93(1):2-7.
3.) Farrell SW, Cortese GM, Lamonte MJ, Blair SN.Cardiorespiratory fitness, different measures of adiposity, and cancer mortality in men.Obesity (Silver Spring). 2007 Dec;15(12):3140-9.
4.) McBride D. Healthful eating and exercise may lower mortality after breast cancer. ONS Connect. 2007 Dec;22(12):27.
5.) Karvinen KH, Courneya KS, North S, Venner P. Associations between exercise and quality of life in bladder cancer survivors: a population-based study.Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):984-90.
6.) Kruk J. Physical activity in the prevention of the most frequent chronic diseases: an analysis of the recent evidence. Asian Pac J Cancer Prev. 2007 Jul-Sep;8(3):325-38.
7.) Lynch BM, Cerin E, Owen N, Aitken JF. Associations of leisure-time physical activity with quality of life in a large, population-based sample of colorectal cancer survivors. Cancer Causes Control. 2007 Sep;18(7):735-42. Epub 2007 May 23.
8.) Milne HM, Gordon S, Guilfoyle A, Wallman KE, Courneya KS. Association between physical activity and quality of life among Western Australian breast cancer survivors. Psychooncology. 2007 Dec;16(12):1059-68.
9.) Stevinson C, Faught W, Steed H, Tonkin K, Ladha AB, Vallance JK, Capstick V, Schepansky A, Courneya KS.Associations between physical activity and quality of life in ovarian cancer survivors. Gynecol Oncol. 2007 Jul;106(1):244-50. Epub 2007 May 9.
10.) Chang SC, Ziegler RG, Dunn B, Stolzenberg-Solomon R, Lacey JV Jr, Huang WY, Schatzkin A, Reding D, Hoover RN, Hartge P, Leitzmann MF. Association of energy intake and energy balance with postmenopausal breast cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):334-41.
11.) Rogers LQ, Courneya KS, Robbins KT, Malone J, Seiz A, Koch L, Rao K, Nagarkar M. Physical activity and quality of life in head and neck cancer survivors. 1: Support Care Cancer. 2006 Oct;14(10):1012-9. Epub 2006 Mar 15.
12.) Hanna L, Adams M. Prevention of ovarian cancer. Best Pract Res Clin Obstet Gynaecol. 2006 Apr;20(2):339-62. Epub 2005 Dec 20.
13.) Pan SY, Ugnat AM, Mao Y. Physical activity and the risk of ovarian cancer: a case-control study in Canada. Int J Cancer. 2005 Nov 1;117(2):300-7.
14.) Courneya KS, Karvinen KH, Campbell KL, Pearcey RG, Dundas G, Capstick V, Tonkin KS. Associations among exercise, body weight, and quality of life in a population-based sample of endometrial cancer survivors. Gynecol Oncol. 2005 May;97(2):422-30.
15.) Vallance JK, Courneya KS, Jones LW, Reiman T. Differences in quality of life between non-Hodgkin’s lymphoma survivors meeting and not meeting public health exercise guidelines. Psychooncology. 2005 Nov;14(11):979-91.
16.) Zhang M, Xie X, Lee AH, Binns CW.Sedentary behaviours and epithelial ovarian cancer risk. Cancer Causes Control. 2004 Feb;15(1):83-9.

Emotional Hygiene and The immune System

1.) Chandrashekara S, Jayashree K, Veeranna HB, Vadiraj HS, Ramesh MN, Shobha A, Sarvanan Y, Vikram YK. Effects of anxiety on TNF-alpha levels during psychological stress. J Psychosom Res. 2007 Jul;63(1):65-9.
2.) Witek-Janusek L, Gabram S, Mathews HL.Psychologic stress, reduced NK cell activity, and cytokine dysregulation in women experiencing diagnostic breast biopsy. Psychoneuroendocrinology. 2007 Jan;32(1):22-35. Epub 2006 Nov 7.
3.) Di Donato A, Di Giampaolo L, Reale M, Dadorante V, Alparone F, Stocchi M, Fattorini E, Di Gioacchino M, Magrini A, Boscolo P. Effect of occupational stress and anxiety on natural killer lymphocyte activity of men and women employed in a university. Int J Immunopathol Pharmacol. 2006 Oct-Dec;19(4 Suppl):79-84.
4.) Barak Y. The immune system and happiness. Autoimmun Rev. 2006 Oct;5(8):523-7. Epub 2006 Mar 21.
5.) Ickovics JR, Milan S, Boland R, Schoenbaum E, Schuman P, Vlahov D; HIV Epidemiology Research Study (HERS) Group.Psychological resources protect health: 5-year survival and immune function among HIV-infected women from four US cities. AIDS. 2006 Sep 11;20(14):1851-60.
6.) Rosenkranz MA, Jackson DC, Dalton KM, Dolski I, Ryff CD, Singer BH, Muller D, Kalin NH, Davidson RJ. Affective style and in vivo immune response: neurobehavioral mechanisms. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11148-52. Epub 2003 Sep 5.

Multiple Vitamins and Cancer

Antioxidants (General) and Cancer

1.) Simone CB 2nd, Simone NL, Simone V, Simone CB. Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 1. Altern Ther Health Med. 2007 Jan-Feb;13(1):22-8.
2.) Simone CB 2nd, Simone NL, Simone V, Simone CB. Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, Part 2. Altern Ther Health Med. 2007 Mar-Apr;13(2):40-7.
3.) Kirsh VA, Hayes RB, Mayne ST, Chatterjee N, Subar AF, Dixon LB, Albanes D, Andriole GL, Urban DA, Peters U; PLCO Trial. Supplemental and dietary vitamin E, beta-carotene, and vitamin C intakes and prostate cancer risk.J Natl Cancer Inst. 2006 Feb 15;98(4):245-54.
4.) Berger MM. Can oxidative damage be treated nutritionally? Clin Nutr. 2005 Apr;24(2):172-83.
5.) Ferguson LR, Philpott M, Karunasinghe N. Dietary cancer and prevention using antimutagens. Toxicology. 2004 May 20;198(1-3):147-59.
6.) Borek C. Dietary antioxidants and human cancer.Integr Cancer Ther. 2004 Dec;3(4):333-41.
7.) Prasad KN. Multiple dietary antioxidants enhance the efficacy of standard and experimental cancer therapies and decrease their toxicity. Integr Cancer Ther. 2004 Dec;3(4):310-22.
8.) Heyland DK, Dhaliwal R, Suchner U, Berger MM. Antioxidant nutrients: a systematic review of trace elements and vitamins in the critically ill patient. Intensive Care Med. 2005 Mar;31(3):327-37. Epub 2004 Dec 17.
9.) Kim YT, Kim JW, Choi JS, Kim SH, Choi EK, Cho NH. Relation between deranged antioxidant system and cervical neoplasia. Int J Gynecol Cancer. 2004 Sep-Oct;14(5):889-95.
10.) Drisko JA, Chapman J, Hunter VJ. The use of antioxidant therapies during chemotherapy. Gynecol Oncol. 2003 Mar;88(3):434-9.
11.) Prasad KN, Cole WC, Kumar B, Prasad KC. Scientific rationale for using high-dose multiple micronutrients as an adjunct to standard and experimental cancer therapies. J Am Coll Nutr. 2001 Oct;20(5Suppl):450S-463S; discussion 473S-475S.
12.) Lamson DW, Brignall MS. Antioxidants in cancer therapy; their actions and interactions with oncologic therapies. Altern Med Rev. 1999 Oct;4(5):304-29.
13.) Prasad KN, Kumar A, Kochupillai V, Cole WC. High doses of multiple antioxidant vitamins: essential ingredients in improving the efficacy of standard cancer therapy. J Am Coll Nutr. 1999
Feb;18(1):13-25.
14.) Lupulescu A. The role of vitamins A, beta-carotene, E and C in cancer cell biology. Int J Vitam Nutr Res. 1994;64(1):3-14.
15.) Stähelin HB. Critical reappraisal of vitamins and trace minerals in nutritional support of cancer patients. Support Care Cancer. 1993 Nov;1(6):295-7.

Vitamin A and Carotenes

1.) Yuan JM, Ross RK, Gao YT, Qu YH, Chu XD, Yu MC. Prediagnostic levels of serum micronutrients in relation to risk of gastric cancer in Shanghai, China. Cancer Epidemiol Biomarkers Prev. 2004 Nov;13(11 Pt 1):1772-80.
2.) Wu K, Erdman JW Jr, Schwartz SJ, Platz EA, Leitzmann M, Clinton SK, DeGroff V, Willett WC, Giovannucci E.Plasma and dietary carotenoids, and the risk of prostate cancer: a nested case-control study. Cancer Epidemiol Biomarkers Prev. 2004 Feb;13(2):260-9.
3.) Kamat AM, Lamm DL. Chemoprevention of bladder cancer. Urol Clin North Am. 2002 Feb;29(1):157-68.
4.) Sato R, Helzlsouer KJ, Alberg AJ, Hoffman SC, Norkus EP, Comstock GW. Prospective study of carotenoids, tocopherols, and retinoid concentrations and the risk of breast cancer. Cancer
Epidemiol Biomarkers Prev. 2002 May;11(5):451-7.
5.) Gann PH, Ma J, Giovannucci E, Willett W, Sacks FM, Hennekens CH,Stampfer MJ. Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis. Cancer Res. 1999 Mar 15;59(6):1225-30.
6.) Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC. ake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst. 1995 Dec 6;87(23):1767-76.
7.) Majewski S, Szmurlo A, Marczak M, Jablonska S, Bollag W.: Synergistic effect of retinoids and interferon alpha on tumor-induced angiogenesis: anti-angiogenic effect on HPV-harboring
tumor-cell lines.Int J Cancer. 1994 Apr 1;57(1):81-5.
8.) Pastorino U, Infante M, Maioli M, et al. Adjuvant treatment of stage I lung cancer with high-dose vitamin A. J Clin Oncol 1993;11:1216–22.

Vitamin C

1.) Wybieralska E, Koza M, Sroka J, Czyz J, Madeja Z. Ascorbic acid inhibits the migration of walker 256 carcinosarcoma cells. Cell Mol Biol Lett. 2008;13(1):103-11. Epub 2007 Oct 29.
2.) Hanck A. Vitamin C and cancer. Int J Vit Nutr Res 1983;(Suppl #24):87–104 [review].
3.) Murata A, Morishige F, Yamaguchi H. Prolongation of survival times of terminal cancer patients by administration of large doses of ascorbate. Int J Vit Nutr Res 1982;(Suppl #23):103–14.
4.) Bussey HJR, DeCosse JJ, Deschner EE, et al. A randomized trial of ascorbic acid in polyposis coli. Cancer 1982;50:1434–9.
5.) Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: reevaluation of prolongation of survival times in terminal human cancer. Proc Natl Acad Sci USA 1978;75:4538–42.
6.) Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer. Proc Natl Acad Sci USA 1976;73:3685–9.

Selenium

1.) Li H, Stampfer MJ, Giovannucci EL, Morris JS, Willett WC, Gaziano JM, Ma J.A prospective study of plasma selenium levels and prostate cancer risk. J Natl Cancer Inst. 2004 May
5;96(9):696-703.
2.) Yu M-W, Horng I-S, Hsu K-H, et al. Plasma selenium levels and risk of hepatocellular carcinoma among men with chronic hepatitis virus infection. Am J Epidemiol 1999;150:367–74.
3.) Knekt P, Marniemi J, Teppo L, et al. Is low selenium status a risk factor for lung cancer? 1998 Nov 15;148(10):975-82.
4.) Scieszka M, Danch A, Machalski M, Drozdz M. Plasma selenium concentration in patients with stomach and colon cancer in the Upper Silesia. Neoplasma 1997;44:395–7.
5.) Toma S, Micheletti A, Giacchero A, et al. Selenium therapy in patients with precancerous and malignant oral cavity lesions: preliminary results.Cancer Detection Prev 1991;15:491–3.
6.) Knekt P, Aromaa A, Maatela J, et al. Serum selenium and subsequent risk of cancer among Finnish men and women. J Natl Cancer Inst 1990;82:864–8.
7.) Burney PGJ, Comstock GW, Morris JS. Serologic precursors of cancer: serum micronutrients and the subsequent risk of pancreatic cancer. Am J Clin Nutr 1989;49:895–900.
8.) Helzlsouer KJ, Comstock GW, Morris JS. Selenium, lycopene, alpha-tocopherol, ß-carotene, retinol, and subsequent bladder cancer. Cancer Res 1989;49:6144–8.
9.) Jaskiewicz K, Marasas WF, Rossouw JE, et al. Selenium and other mineral elements in populations at risk for esophageal cancer. Cancer 1988;62:2635–9.
10.) Medina D, Morrison DG. Current ideas on selenium as a chemopreventative agent. Pathol Immunopathol Res 1988;7:187–99.
11.) Fex G, Pettersson B, Akesson B. Low plasma selenium as a risk factor for cancer death in middle-aged men. Nutr Cancer 1987;10:221–9.
12.) Medina D. Mechanisms of selenium inhibition of tumorigenesis. Adv Exp Med Biol 1986;206:465–72.
13.) Willett WC, Polk BF, Morris JS, et al. Prediagnostic serum Selenium and risk of cancer. Lancet 1983;42:130–4.
14.) Beisel WR. Single nutrients and immunity. Am J Clin Nutr 1982;35:417–68.
15.) Shamberger RJ, Rukoven E, Lonfield AK, et al. Antioxidants and cancer. Selenium in the blood of normals and cancer patients. J Natl Cancer Inst 1973;4:863–70.

Vitamin D

1.) Lappe J, Travers-Gustafson D, Davies K, Recker R, Heaney R. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. American Journal of Clinical Nutrition. Am J Clin Nutr. 2007 Jun;85(6):1586-91.
2.) Ma Y, et al. Study presented at the 2007 centennial meeting of the American Association for Cancer Research (AACR), April 14 to 18, 2007, Los Angeles.
3.)Holick MF.: Vitamin D: Its role in cancer prevention and treatment. Prog Biophys Mol Biol. 2006 Mar 10;
4.) Schwartz GG, Eads D, Rao A, Cramer SD, Willingham MC, Chen TC, Jamieson DP, Wang L, Burnstein KL, Holick MF, Koumenis C.:Pancreatic cancer cells express 25-hydroxyvitamin D-1
alpha-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3.Carcinogenesis. 2004 Jun;25(6):1015-26. Epub 2004 Jan 23.
5.) Wietrzyk J, Pelczynska M, Madej J, Dzimira S, Kusnierczyk H, Kutner A, Szelejewski W, Opolski A.: Toxicity and antineoplastic effect of (24R)-1,24-dihydroxyvitamin D3 (PRI-2191).Steroids. 2004 Sep;69(10):629-35.
6.) Vegesna V, O’Kelly J, Said J, Uskokovic M, Binderup L, Koeffle HP.: Ability of potent vitamin D3 analogs to inhibit growth of prostate cancer cells in vivo. Anticancer Res. 2003 Jan-Feb;23(1A):283-9.
7.) Grant WB. An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation. Cancer. 2002 Mar 15;94(6):1867-75.
8.) Majewski S, Skopinska M, Marczak M, Szmurlo A, Bollag W, Jablonska S.: Vitamin D3 is a potent inhibitor of tumor cell-induced angiogenesis. J Investig Dermatol Symp Proc. 1996 Apr;1(1):97-101.
9.) James SY, Mackay AG, Colston KW. Effects of 1,25 dihydroxyvitamin D3 and its analogues on induction of apoptosis in breast cancer cells. J Steroid Biochem Mol Biol. 1996
Jul;58(4):395-401.
10.) Schwartz GG, Hill CC, Oeler TA, Becich MJ, Bahnson RR.1,25-Dihydroxy-16-ene-23-yne-vitamin D3 and prostate cancer cell proliferation in vivo. Urology. 1995 Sep;46(3):365-9.
11.) Majewski S, Szmurlo A, Marczak M, Jablonska S, Bollag W.: Inhibition of tumor cell-induced angiogenesis by retinoids, 1,25-dihydroxyvitamin D3 and their combination.Cancer Lett. 1993 Nov 30;75(1):35-9.

Omega 3 Essential Fatty Acids

1.) Colomer R, Moreno-Nogueira JM, García-Luna PP, García-Peris P, García-de-Lorenzo A, Zarazaga A, Quecedo L, del Llano J, Usán L, Casimiro C. N-3 fatty acids, cancer and cachexia: a systematic review of the literature. Br J Nutr. 2007 May;97(5):823-31.
2.) Zhang W, Long Y, Zhang J, Wang C. Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer cells. J Huazhong Univ Sci Technolog Med Sci. 2007 Oct;27(5):547-50.
3.) Dauchy RT, Dauchy EM, Davidson LK, Krause JA, Lynch DT, Tirrell PC, Tirrell RP, Sauer LA, Van der Riet P, Blask DE. Inhibition of fatty acid transport and proliferative activity in tissue-isolated human squamous cell cancer xenografts perfused in situ with melatonin or eicosapentaenoic or conjugated linoleic acids. Comp Med. 2007 Aug;57(4):377-82.
4.) Chen J, Power KA, Mann J, Cheng A, Thompson LU. Flaxseed alone or in combination with tamoxifen inhibits MCF-7 breast tumor growth in ovariectomized athymic mice with high circulating levels of estrogen. Exp Biol Med (Maywood). 2007 Sep;232(8):1071-80.
5.) Kolar SS, Barhoumi R, Callaway ES, Fan YY, Wang N, Lupton JR, Chapkin RS. Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytes. Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G935-43. Epub 2007 Aug 23.
6.) Kato T, Kolenic N, Pardini RS. Docosahexaenoic acid (DHA), a primary tumor suppressive omega-3 fatty acid, inhibits growth of colorectal cancer independent of p53 mutational status. Nutr Cancer. 2007;58(2):178-87.
7.) Espada CE, Berra MA, Martinez MJ, Eynard AR, Pasqualini ME. Effect of Chia oil (Salvia Hispanica) rich in omega-3 fatty acids on the eicosanoid release, apoptosis and T-lymphocyte tumor infiltration in a murine mammary gland adenocarcinoma. Prostaglandins Leukot Essent Fatty Acids. 2007 Jul;77(1):21-8. Epub 2007 Jul 6.
8.) Saarinen NM, Power K, Chen J, Thompson LU. Flaxseed attenuates the tumor growth stimulating effect of soy protein in ovariectomized athymic mice with MCF-7 human breast cancer xenografts. Int J Cancer. 2006 Aug 15;119(4):925-31.
9.) Shirota T, Haji S, Yamasaki M, Iwasaki T, Hidaka T, Takeyama Y, Shiozaki H, Ohyanagi H. Apoptosis in human pancreatic cancer cells induced by eicosapentaenoic acid. Nutrition. 2005 Oct;21(10):1010-7.
10.) Schley PD, Jijon HB, Robinson LE, Field CJ. Mechanisms of omega-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells. Breast Cancer Res Treat. 2005 July;92(2):187-95.
11.) de Deckere EA. Possible beneficial effect of fish and fish n-3 polyunsaturated fatty acids in breast and colorectal cancer. Eur J Cancer Prev. 1999 Jul;8(3):213-21.
12.) Chang WL, Chapkin RS, Lupton JR. Fish oil blocks azoxymethane-induced rat colon tumorigenesis by increasing cell differentiation and apoptosis rather than decreasing cell proliferation. J Nutr. 1998 Mar;128(3):491-7.
13.) Bagga D, Capone S, Wang HJ, Heber D, Lill M, Chap L, Glaspy JA. Dietary modulation of omega-3/omega-6 polyunsaturated fatty acid ratios in patients with breast cancer. J Natl Cancer Inst. 1997 Aug 6;89(15):1123-31.

Di-indolymethanes (DIM, IC3)

1.) Moiseeva EP, Almeida GM, Jones GD, Manson MM.Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. Mol Cancer Ther. 2007 Nov;6(11):3071-9.
2.) Weng JR, Tsai CH, Kulp SK, Wang D, Lin CH, Yang HC, Ma Y, Sargeant A, Chiu CF, Tsai MH, Chen CS. A potent indole-3-carbinol derived antitumor agent with pleiotropic effects on multiple signaling pathways in prostate cancer cells. Cancer Res. 2007 Aug 15;67(16):7815-24.
3.) Pappa G, Strathmann J, Löwinger M, Bartsch H, Gerhäuser C. Quantitative combination effects between sulforaphane and 3,3′-diindolylmethane on proliferation of human colon cancer cells in vitro. Carcinogenesis. 2007 Jul;28(7):1471-7. Epub 2007 Feb 28.
4.) Pappa G, Lichtenberg M, Iori R, Barillari J, Bartsch H, Gerhäuser C. Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. Mutat Res. 2006 Jul 25;599(1-2):76-87. Epub 2006 Feb 24.
5.) Bhuiyan MM, Li Y, Banerjee S, Ahmed F, Wang Z, Ali S, Sarkar FH. Down-regulation of androgen receptor by 3,3′-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells. Cancer Res. 2006 Oct 15;66(20):10064-72.
6.) Aggarwal BB, Ichikawa H. Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle. 2005 Sep;4(9):1201-15. Epub 2005 Sep 6.
7.) Chinni SR, Li Y, Upadhyay S, Koppolu PK, Sarkar FH. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells. Oncogene. 2001 May 24;20(23):2927-36.
8.) Cover CM, Hsieh SJ, Cram EJ, et al. Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells. Cancer Res 1999;59:1244–51.

Turmeric (Curcumin)

1.) Ji C, Cao C, Lu S, Kivlin R, Amaral A, Kouttab N, Yang H, Chu W, Bi Z, Di W, Wan Y. Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells.Cancer Chemother Pharmacol. 2008 Jan 23 [Epub ahead of print].
2.) Steward WP, Gescher AJ. Curcumin in cancer management: Recent results of analogue design and clinical studies and desirable future research. Mol Nutr Food Res. 2008 Jan 9 [Epub ahead of print].
3.) Shankar S, Ganapathy S, Chen Q, Srivastava RK. Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis. Mol Cancer. 2008 Jan 29;7(1):16 [Epub ahead of print]
4.) Moiseeva EP, Almeida GM, Jones GD, Manson MM. Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. Mol Cancer Ther. 2007 Nov;6(11):3071-9.
5.) Shankar S, Chen Q, Sarva K, Siddiqui I, Srivastava RK. Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells: molecular mechanisms of apoptosis, migration and angiogenesis. J Mol Signal. 2007 Oct 4;2:10.
6.) Shankar S, Srivastava RK. Bax and Bak genes are essential for maximum apoptotic response by curcumin, a polyphenolic compound and cancer chemopreventive agent derived from turmeric, Curcuma longa. Carcinogenesis. 2007 Jun;28(6):1277-86. Epub 2007 Feb 2.
7.) Shankar S, Srivastava RK. Involvement of Bcl-2 family members, phosphatidylinositol 3′-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer. Int J Oncol. 2007 Apr;30(4):905-18.
8.) Somers-Edgar TJ, Scandlyn MJ, Stuart EC, Le Nedelec MJ, Valentine SP, Rosengren RJ. The combination of epigallocatechin gallate and curcumin suppresses ERalpha-breast cancer cell growth in vitro and in vivo. Int J Cancer. 2007 Dec 20 [Epub ahead of print].
9.) Chen A, Xu J, Johnson AC. Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1. Oncogene. 2006 Jan 12;25(2):278-87.
10.) Wahl H, Tan L, Griffith K, Choi M, Liu JR. Curcumin enhances Apo2L/TRAIL-induced apoptosis in chemoresistant ovarian cancer cells. Gynecol Oncol. 2007 Apr;105(1):104-12. Epub 2006 Dec 15.
11.) Chen J, Wanming D, Zhang D, Liu Q, Kang J.Water-soluble antioxidants improve the antioxidant and anticancer activity of low concentrations of curcumin in human leukemia cells. Pharmazie. 2005 Jan;60(1):57-61.
12.) Deeb DD, Jiang H, Gao X, Divine G, Dulchavsky SA, Gautam SC. Chemosensitization of hormone-refractory prostate cancer cells by curcumin to TRAIL-induced apoptosis. J Exp Ther Oncol. 2005;5(2):81-91.
13.)Dobrovolskaia MA, Kozlov SV.: Inflammation and cancer: when NF-kappaB amalgamates the perilous partnership. Curr Cancer Drug Targets. 2005 Aug;5(5):325-44.
14.) Deeb D, Jiang H, Gao X, Hafner MS, Wong H, Divine G, Chapman RA, Dulchavsky SA, Gautam SC. Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing gand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation. Mol Cancer Ther. 2004 Jul;3(7):803-12.
15.) Van Erk MJ, Teuling E, Staal YC, Huybers S, Van Bladeren PJ, Aarts JM, Van Ommen B. Time- and dose-dependent effects of curcumin on gene expression in human colon cancer cells. J Carcinog. 2004 May 12;3(1):8.
16.)Ernst P.: The role of inflammation in the pathogenesis of gastric cancer. Aliment Pharmacol Ther. 1999 Mar;13 Suppl 1:13-8
17.) Menon LG, Kuttan R, Kuttan G. Anti-metastatic activity of curcumin and catechin. Cancer Lett 1999;141:159–65.
18.) Khafif A, Schantz SP, Chou TC, Edelstein D, Sacks PG. uantitation of chemopreventive synergism between (-)-epigallocatechin-3-gallate and curcumin in normal, premalignant and malignant human oral epithelial cells. Carcinogenesis. 1998

Melatonin

1.) Lissoni P, Barni S, Mandalà, et al. Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status. Eur J Cancer 1999;35:1688–92.
2.) Lissoni P, Cazzanga M, Tancini G, et al. Reversal of clinical resistance to LHRH analogue in metastatic prostate cancer by the pineal hormone melatonin: efficacy of LHRH analogue plus melatonin in patients progressing on LHRH analogue alone. Eur Urol 1997;31:178–81.
3.) Lissoni P, Paolorossi F, Tancini G, et al. Is there a role for melatonin in the treatment of neoplastic cachexia? Eur J Cancer 1996;32A:1340–3.
4.) Lissoni P, Paolorossi F, Tancini G, et al. A phase II study of tamoxifen plus melatonin in metastatic solid tumour patients. Br J Cancer 1996;74:1466–8.
5.) Lissoni P, Brivio O, Brivio F, et al. Adjuvant therapy with the pineal hormone melatonin in patients with lymph node relapse due to malignant melanoma. J Pineal Res 1996;21:239–42.
6.) Lissoni P, Barmo S. Meregalli S, et al. Modulation of cancer endocrine therapy by melatonin: a phase II study of tamoxifen plus melatonin in metastatic breast cancer patients progressing under tamoxifen alone. Br J Cancer 1995;71:854–6.
7.) Reiter RJ, Melchiorri D, Sewerynek E, Poeggeler B, Barlow-Walden L, Chuang J, Ortiz GG, Acuna-Castroviejo D.: A review of the evidence supporting melatonin’s role as an antioxidant.J Pineal Res. 1995 Jan;18(1):1-11.
8.) Neri B, Fiorelli C, Moroni F, et al. Modulation of human lymphoblastoid interferon activity by melatonin in metastatic renal cell carcinoma. Cancer 1994;73:315–9.
9.) Lissoni P, Barni S, Cazzaniga M, Ardizzoia A, Rovelli F, Brivio F, Tancini G.: Efficacy of the concomitant administration of the pineal hormone melatonin in cancer immunotherapy with low-dose IL-2 in patients with advanced solid tumors who had progressed on IL-2 alone. Oncology. 1994 Jul-Aug;51(4):344-7.
10.) Lissoni P, Barni S, Ardizzoia A, et al. A randomized study with the pineal hormone melatonin versus supportive care alone in patients with brain metastases due to solid neoplasms. Cancer 1994;73:699–701.
11.) Lissoni P, Barni S, Tancini G, et al. A randomised study with subcutaneous low-dose interleukin 2 alone vs interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma. Br J Cancer 1994;69:196–9.
12.) Aldeghi R, Lissoni P, Barni S, et al. Low-dose interlekin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first-line therapy in locally advanced or metastatic hepatocellular carcinoma. Eur J Cancer 1994;30A:167–70.
13.) Lissoni P, Brivio F, Ardizzoia A, et al. Subcutaneous therapy with low-dose interlekin-2 plus the neurohormone melatonin in metastatic gastric cancer patients with low performance status. Tumori 1993;79:401–4.
14.) Lissoni P, Barni S, Ardizzoia A, et al. Randomized study with the pineal hormone melatonin versus supportive care alone in advanced nonsmall cell lung cancer resistant to a first-line chemotherapy containing cisplatin. Oncology 1992;49:336–9.
15.) Lissoni P, Barni S, Crispino S, et al. Endocrine and immune effects of melatonin therapy in metastatic cancer patients. Eur J Cancer Clin Oncol 1989;25:789–95.

CoQ10 – 50mg

Super-Energizer and Potent Antioxidant

CoQ10 is a naturally-occurring antioxidant produced in the human body. It is vitally involved in energy production. CoQ10 functions as an “energizer” to mitochondria, the body’s energy producing units. Mitochondria, which produce energy the body’s “energy currency,” ATP, require CoQ10 to “spark” their production of energy units (ATP). Muscles, and the heart in particular, have high requirements for CoQ10.

CoQ10 is a potent antioxidant beneficial for:

Heart Disease (angina, arrhythmia, atherosclerosis, cardiomyopathy, heart failure, congestive heart failure, myocardial infarction (1-18)
High Blood Pressure (1,3,4,14, 53, 55)
Neurological disease (Alzheimer’s, Huntington’s, Parkinson’s) (19-37)
Immune deficiency and AIDS (40-45,52)
Periodontal disease (38-39)
Cancer (40, 44-49)
Chemotherapy side-effects (50-52)
Diabetes (53-56)
Muscular dystrophy (57-58)
fatigue / chronic fatigue / fibromyalgia (59-61)
migraine headache (62-63)
enhancing athletic performance (64-68)
male infertility (69-73)

CoQ10 is produced by the body, but age, nutrient deficiencies, disease and some medications can lower the body’s CoQ10 levels. Cholesterol-lowering drugs (statins) deplete CoQ10. (15,54,74-77)

Studies have shown that the oil-preserved form is up to 3 times better absorbed than other forms. (78-80)

Although many claims are currently made for a “new” form (ubiquinol) being “more absorbable” than ubiquinone, this has never been proven or well-studied. Learn more about this issue here: Ubiquinone (CoQ10) versus Ubiquinol: Which Is Better?

CoQ10 and it’s use in CHF (Congestive Heart Failure):

http://www.ncbi.nlm.nih.gov/pubmed/19966871
“… Coenzyme Q10 (CoQ10) is essential for electron transport within the mitochondria and hence for ATP generation and cellular energy production. We recently demonstrated that plasma levels of CoQ10 are an independent predictor of survival in a cohort of 236 patients with chronic heart failure (CHF) followed for a median of 2.69 years. This is consistent with previous studies which have shown myocardial CoQ10 depletion in CHF, and correlated with the severity of the underlying disorder. Several intervention studies have been undertaken with CoQ10 in CHF, including randomized controlled trials with mostly positive outcomes in relation to improvement in plasma levels of CoQ10. A meta-analysis showed that CoQ10 resulted in an improvement in ejection fraction of 3.7% (95%CI 1.59-5.77) and the mean increase in cardiac output was 0.28 L/minute (95%CI 0.03-0.53). In a subgroup analysis, studies with patients not taking ACE inhibitors found a 6.7% increase in ejection fraction. The ongoing Q-SYMBIO trial will address whether CoQ10 supplementation improves survival in CHF patients. CoQ10 depletion may also be a contributory factor for why statin intervention has not improved outcomes in CHF. There is an emerging evidence base in support of CoQ10 as an adjunctive therapy in CHF.”

http://faculty.washington.edu/ely/coenzq10.html
“…The majority of the clinical studies concerned the treatment of heart disease and were remarkably consistent in their conclusions: that treatment with CoQ10 significantly improved heart muscle function while producing no adverse effects or drug interactions. …”

Dr. Myatt’s Conclusion:
CoQ10 is beneficial for nearly every type of Heart Disease (angina, arrhythmia, atherosclerosis, cardiomyopathy, heart failure, congestive heart failure, myocardial infarction (1-18)

Suggested dose:

50-100 mg per day for health maintenance and anti-aging / longevity programs.

Each Capsule contains:

50 mg capsules are Wellness Club brand oil-preserved CoQ10 in easy to swallow gel Caps with Vitamin E & Beta carotene as natural preservatives.

Notes

If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

Manufactured by a Drug GMP audited facility.

**Based on 2000 calorie diet.

References:

1.) Adarsh K, Kaur H, Mohan V. Coenzyme Q10 (CoQ10) in isolated diastolic heart failure in hypertrophic cardiomyopathy (HCM). Biofactors. 2008;32(1-4):145-9.
2.) Berman M, Erman A, Ben-Gal T, Dvir D, Georghiou GP, Stamler A, Vered Y, Vidne BA, Aravot D. Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. Clin Cardiol. 2004 May;27(5):295-9.
3.) Hodgson JM, Watts GF, Playford DA, Burke V, Croft KD. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr. 2002 Nov;56(11):1137-42.
4.) Kumar A, Kaur H, Devi P, Mohan V. Role of Coenzyme Q10 (CoQ10) in Cardiac disease, Hypertension and Meniere- like syndrome. Pharmacol Ther. 2009 Jul 25. [Epub ahead of print]
5.) Langsjoen PH, Folkers K, Lyson K, Muratsu K, Lyson T, Langsjoen P. Pronounced increase of survival of patients with cardiomyopathy when treated with coenzyme Q10 and conventional therapy. Int J Tissue React. 1990;12(3):163-8.
6.) Langsjoen PH, Folkers K, Lyson K, Muratsu K, Lyson T, Langsjoen P. Effective and safe therapy with coenzyme Q10 for cardiomyopathy. Klin Wochenschr. 1988 Jul 1;66(13):583-90.
7.) Langsjoen P, Langsjoen A, Willis R, and Folkers K. The Aging Heart: Reversal of Diastolic Dysfunction Through the Use of Oral CoQ10 in the Elderly. Anti-Aging Medical Therapeutics. Klatz RM and Goldman R (eds.). Health Quest Publications. 1997;113-120.
8.) Langsjoen PH, Langsjoen A, Willis R, Folkers K. Treatment of hypertrophic cardiomyopathy with coenzyme Q10. Mol Aspects Med. 1997;18(S):s145-s151.
9.) Langsjoen PH, Vadhanavikit S, Folkers K. Response of patients in classes III and IV of cardiomyopathy to therapy in a blind and crossover trial with coenzyme Q10. Proc Natl Acad Sci U S A. 1985 Jun;82(12):4240-4.
10.) Mabuchi H, Higashikata T, Kawashiri M, Katsuda S, Mizuno M, Nohara A, Inazu A, Koizumi J, Kobayashi J. Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients. Journal of Atheroscler Thromb. 2005;12(2):111-9.
11.) Molyneux SL, Florkowski CM, George PM, Pilbrow AP, Frampton CM, Lever M, Richards AM. Coenzyme Q10: an independent predictor of mortality in chronic heart failure. J Am Coll Cardiol. 2008 Oct 28;52(18):1435-41.
12.) Mortensen SA. Overview on coenzyme Q10 as adjunctive therapy in chronic heart failure. Rationale, design and end-points of “Q-symbio”–a multinational trial. Biofactors. 2003;18(1-4):79-89.
13.) Mortensen S.A., Vadhanavikit S., Muratsu K., Folkers K. (1990) Coenzyme Q10: Clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure. In: Int. J. Tissue React., Vol. 12 (3), pp 155-162.
14.) Rosenfeldt F, Hilton D, Pepe S, Krum H. Systematic review of effect of coenzyme Q10 in physical exercise, hypertension, and heart failure. Biofactors. 2003;18(1-4):91-100.
15.) Silver MA, Langsjoen PH, Szabo S, Patil H, Zelinger A. Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction. Am J Cardiol. 2004 Nov 15;94(10):1306-10.
16.) Singh RB; Wander GS et al Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc Drugs Ther, 12(4):347-53 1998 Sep.
17.) Singh RB; Wander GS et al Cardiovasc Drugs Ther, 12(4):347-53 1998 Sep.
18.) Weant KA, Smith KM. The role of coenzyme Q10 in heart failure. Ann Pharmacother. 2005;39(9):1522-6.
19.) Beal MF. Coenzyme Q10 as a possible treatment for neurodegenerative diseases. Free Radic Res. 2002 Apr;36(4):455-60.
20.) Fallon J, Matthews RT, Hyman BT, Beal MF. MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress. Exp Neurol. 1997 Mar;144(1):193-8.
21.) Feigin A, Kieburtz K, Como P, Hickey C, Claude K, Abwender D, Zimmerman C, Steinberg K, Shoulson I. Assessment of coenzyme Q10 tolerability in Huntington’s disease. Mov Disord. 1996;11(3):321-323.
22.) Ferrante KL, Shefner J, Zhang H, et al. Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS. Neurology. 2005 Dec 13;65(11):1834-1836.
23.) Flint Beal M, Matthews RT, Tieleman A, Shults CW. Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain Res. 1998;783:109-114.
24.) Flint Beal M, Matthews RT. Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseases. Mol Aspects Med. 1997;18(S);s169-s179.
25.) Flint Beal M, Henshaw DR, Jenkins BG, Rosen BR, Schulz JB. Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate. Ann Neurol. 1994;36:882-888.
26.) Jenkins BG, Brouillet E, Chen YC, Storey E, Schulz JB, Kirschner P, Beal MF, Rosen BR. Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging. J Cereb Blood Flow Metab. 1996 May;16(3):450-61.
27.) Koroshetz WJ, Jenkins BG, Rosen BR, Flint Beal M. Energy metabolism defects in Huntington’s disease and effects of coenzyme Q10. Ann Neurol. 1997;41:160-165.
28.) Matthews RT, Yang L, Brown S, Baik MF. Coenzyme Q10 administration increases brain mitochondrial concentration and exerts neuroprotective effects. Proc Natl Acad Sci USA. 1998;95:8892-8897.
29.) Schilling G, Coonfield ML, Ross CA, Borchelt DR. Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington’s disease transgenic mouse model. Neurosci Lett. 2001 Nov 27;315(3):149-53.
30.) Shults CW, Oakes D, Kieburtz K, et al. Effects of Coenzyme Q10 in Early Parkinson’s Disease. Arch Neurol. 2002:59:1541-1550.
31.) Schulz B, Matthews RT, Henshaw DR, Beal MF. Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases. Neuroscience. 1996;71(4):1043-1048.
32.) Shults CW, Flint Beal M, Fontaine D, Nakano K, Haas RH. Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients. Neurology. 1998;50:793-795.
33.) Shults CW, Haas RH, Passov D, Beal MF. Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects. Ann Neurol. 1997 Aug;42(2):261-4.
34.) Schulz JB, Henshaw R, Matthews RT, Flint Beal M. Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity. Exp Neurol. 1995;132:279-283.
35.) Shults CW, Flint Beal M, Song D, Fontaine D. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson’s disease. Exp Neurol. 2004 Aug;188(2):491-4.
36.) The Huntington Study Group. A Randomized, Placebo-Controlled Trial of Coenzyme Q10 and Remacemide in Huntington’s Disease. Neurology. 2001:57:397-404.
37.) Yang L, Calingasan NY, Wille EJ, Cormier K, Smith K, Ferrante RJ, Beal MF. Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson’s and Huntington’s diseases. J Neurochem. 2009 Jun;109(5):1427-39.
38.) Hanioka T, Tanaka M, Ojima M, Shizukuishi S, Folkers K. Effect of topical application of coenzyme Q10 on adult periodontitis. Mol Aspects Med. 1994;15 Suppl:s241-8.
39.)Nakamura R, Littarru GP, Folkers K, Wilkinson EG. Study of CoQ10-enzymes in gingiva from patients with periodontal disease and evidence for a deficiency of coenzyme Q10. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1456-60.
40.) Folkers K, Hanioka T, Xia LJ, McRee JT Jr, Langsjoen P. Coenzyme Q10 increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS related complex. Biochem Biophys Res Commun. 1991 Apr 30;176(2):786-91.
41.) Folkers K, Langsjoen P, Nara Y, Muratsu K, Komorowski J, Richardson PC, Smith TH. Biochemical deficiencies of coenzyme Q10 in HIV-infection and exploratory treatment. Biochem Biophys Res Commun. 1988 Jun 16;153(2):888-96.
42.) Folkers K, Wolaniuk A. Research on coenzyme Q10 in clinical medicine and in immunomodulation. Drugs Exp Clin Res. 1985;11(8):539-45.
43.) Ravaglia G, Forti P, Maioli F, Bastagli L, Facchini A, Mariani E, Savarino L, Sassi S, Cucinotta D, Lenaz G. Effect of micronutrient status on natural killer cell immune function in healthy free-living subjects aged >/=90 y. Am J Clin Nutr. 2000 Feb;71(2):590-8.
44.) Folkers K, Morita M, McRee J Jr. The activities of coenzyme Q10 and vitamin B6 for immune responses. Biochem Biophys Res Commun. 1993 May 28;193(1):88-92.
45.) Folkers K, Brown R, Judy WV, Morita M. Biochem Biophys Res Commun. 1993 Apr 15;192(1):241-5.Survival of cancer patients on therapy with coenzyme Q10.
46.) Judy WV. Nutritional intervention in cancer prevention and treatment. American College for Advancement in Medicine Spring Conference, Ft. Lauderdale, FL. May 3, 1998.
47.) Lockwood K, Moesgaard S, Folkers K. Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10. Biochem Biophys Res Commun 1994;199:1504–8.
47.) Lockwood K, Moesgaard S, Hanioka T, Folkers K. Apparent partial remission of breast cancer in ‘high risk’ patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10. Mol Aspects Med. 1994;15 Suppl:s231-40.
48.) Lockwood K, Moesgaard S, Yamamoto T, Folkers K. Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases. Biochem Biophys Res Commun 1995;212:172–7.
49.) Perumal SS, Shanthi P, Sachdanandam P. Energy-modulating vitamins–a new combinatorial therapy prevents cancer cachexia in rat mammary carcinoma.Br J Nutr. 2005 Jun;93(6):901-9.
50.) Conklin KA. Coenzyme q10 for prevention of anthracycline-induced cardiotoxicity. Integr Cancer Ther. 2005 Jun;4(2):110-30.
51.) Domae N, Sawada H, Matsuyama E, Konishi T, Uchino H. Cardiomyopathy and other chronic toxic effects induced in rabbits by doxorubicin and possible prevention by coenzyme Q10. Cancer Treat Rep. 1981 Jan-Feb;65(1-2):79-91.
52.) Folkers K, Wolaniuk A. Research on coenzyme Q10 in clinical medicine and in immunomodulation. Drugs Exp Clin Res. 1985;11(8):539-45.
53.) Chew GT, Watts GF, Davis TM, Stuckey BG, Beilin LJ, Thompson PL, Burke V, Currie PJ. Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2 diabetic subjects with left ventricular diastolic dysfunction. Diabetes Care. 2008 Aug;31(8):1502-9. Epub 2008 May 16.
54.) Hamilton SJ, Chew GT, Watts GF. Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. Diabetes Care. 2009 May;32(5):810-2. Epub 2009 Feb 19.
55.) Hodgson JM, Watts GF, Playford DA, Burke V, Croft KD. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr. 2002 Nov;56(11):1137-42.
56.) Watts GF, Playford DA, Croft KD, Ward NC, Mori TA, Burke V. Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus. Diabetologia. 2002 Mar;45(3):420-6.
57.) Folkers K, Simonsen R.Two successful double-blind trials with coenzyme Q10 (vitamin Q10) on muscular dystrophies and neurogenic atrophies. Biochim Biophys Acta. 1995 May 24;1271(1):281-6.
58.) Folkers K, Wolaniuk J, Simonsen R, Morishita M, Vadhanavikit S.Biochemical rationale and the cardiac response of patients with muscle disease to therapy with coenzyme Q10. Proc Natl Acad Sci U S A. 1985 Jul;82(13):4513-6.
59.) Bentler SE, Hartz AJ, Kuhn EM. Prospective observational study of treatments for unexplained chronic fatigue. J Clin Psychiatry. 2005 May;66(5):625-32.
60.) Cordero MD, Moreno-Fernández AM, deMiguel M, Bonal P, Campa F, Jiménez-Jiménez LM, Ruiz-Losada A, Sánchez-Domínguez B, Sánchez Alcázar JA, Salviati L, Navas P. Coenzyme Q10 distribution in blood is altered in patients with fibromyalgia. Clin Biochem. 2009 May;42(7-8):732-5. Epub 2008 Dec 25.
61.) Lister RE. An open, pilot study to evaluate the potential benefits of coenzyme Q10 combined with Ginkgo biloba extract in fibromyalgia syndrome. J Int Med Res. 2002 Mar-Apr;30(2):195-9.
62.) Sándor PS, Di Clemente L, Coppola G, Saenger U, Fumal A, Magis D, Seidel L, Agosti RM, Schoenen J. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology. 2005 Feb 22;64(4):713-5.
63.) Rozen TD, Oshinsky ML, Gebeline CA, Bradley KC, Young WB, Shechter AL, Silberstein SD. Open label trial of coenzyme Q10 as a migraine preventive. Cephalalgia. 2002 Mar;22(2):137-41.
64.) Cohen B, Gold D. Mitochondrial cytopathy in adults: What we know so far. Cleveland Clinic J Medicine 2001, 68:7,625-642.
65.) Cooke M, Iosia M, Buford T, Shelmadine B, Hudson G, Kerksick C, Rasmussen C, Greenwood M, Leutholtz B, Willoughby D, Kreider R.Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. J Int Soc Sports Nutr. 2008 Mar 4;5:8.
66.) Gökbel H, Gül I, Belviranl M, Okudan N. The Effects Of Coenzyme Q10 Supplementation on Performance During Repeated Bouts of Supramaximal Exercise in Sedentary Men. J Strength Cond Res. 2009 Jul 28. [Epub ahead of print]
67.) Kon M, Tanabe K, Akimoto T, Kimura F, Tanimura Y, Shimizu K, Okamoto T, Kono I. Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. Br J Nutr. 2008 Feb 20;1-7. 68.) Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y. Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition. 2008 Feb 11.
69.) Balercia G, Buldreghini E, Vignini A, Tiano L, Paggi F, Amoroso S, Ricciardo-Lamonica G, Boscaro M, Lenzi A, Littarru G. Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial. Fertil Steril. 2009 May;91(5):1785-92. 70.) Balercia G, Mancini A, Paggi F, Tiano L, Pontecorvi A, Boscaro M, Lenzi A, Littarru GP. COENZYME Q10 AND MALE INFERTILITY. J Endocrinol Invest. 2009 May 21. [Epub ahead of print]
71.) Balercia G, Mosca F, Mantero F, Boscaro M, Mancini A, Ricciardo-Lamonica G, Littarru G. Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril. 2004 Jan;81(1):93-8.
72.) Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol. 2007 Sep;37(1):31-7.
73.) Mancini A, De Marinis L, Littarru GP, Balercia G. An update of Coenzyme Q10 implications in male infertility: biochemical and therapeutic aspects. Biofactors. 2005;25(1-4):165-74.
74.) Joy TR, Hegele RA. Narrative review: statin-related myopathy. Ann Intern Med. 2009 Jun 16;150(12):858-68.
75.) Langsjoen PH, Langsjoen AM. The clinical use of HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10. A review of animal and human publications. Biofactors. 2003;18(1-4):101-11.
76.) Langsjoen PH, Langsjoen JO, Langsjoen AM, Lucas LA. Treatment of statin adverse effects with supplemental Coenzyme Q10 and statin drug discontinuation. Biofactors. 2005;25(1-4):147-52.
77.) Caso G, Kelly P, McNurlan MA, Lawson WE. Effect of coenzyme q10 on myopathic symptoms in patients treated with statins. Am J Cardiol. 2007 May 15;99(10):1409-12. Epub 2007 Apr 3.
78.) Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007 Jun;7 Suppl:S78-88. Epub 2007 Mar 27.
79.) Chopra RK, Goldman R, Sinatra ST, Bhagavan HN. Relative bioavailability of coenzyme Q10 formulations in human subjects. Int J Vitam Nutr Res 1998;68:109–13.
80.)Weiss M, Mortensen SA, Rassig MR, et al. Bioavailability of four oral coenzyme Q10 formulations in healthy volunteers. Molec Aspects Med 1994;15:273–80.

CoQ10 (ubiquinone)

Super-Energizer and Potent Antioxidant

CoQ10 is a potent antioxidant beneficial for:

Heart Disease (angina, arrhythmia, atherosclerosis, cardiomyopathy, heart failure, congestive heart failure, myocardial infarction (1-18)
High Blood Pressure (1,3,4,14, 53, 55)
Neurological disease (Alzheimer’s, Huntington’s, Parkinson’s) (19-37)
Immune deficiency and AIDS (40-45,52)
Periodontal disease (38-39)
Cancer (40, 44-49)
Chemotherapy side-effects (50-52)
Diabetes (53-56)
Muscular dystrophy (57-58)
fatigue / chronic fatigue / fibromyalgia (59-61)
migraine headache (62-63)
enhancing athletic performance (64-68)
male infertility (69-73)

CoQ10 is produced by the body, but age, nutrient deficiencies, disease and some medications can lower the body’s CoQ10 levels. Cholesterol-lowering drugs (statins) deplete CoQ10. (15,54,74-77)

Studies have shown that the oil-preserved form is up to 3 times better absorbed than other forms. (78-80)

CoQ10 and it’s use in CHF (Congestive Heart Failure):

Suggested dose:

50-100 mg per day for health maintenance and anti-aging / longevity programs.

200 to 400 mg per day for heart problems, cancer, weight loss programs and other indications.

Studies performed by the National Institutes of Health (NIH) using Vitaline ™ brand CoQ10, have used 300-400 mg (or more under medical direction) per day.

Each Capsule contains:

50 or 100 mg capsules are Wellness Club brand oil-preserved CoQ10 in easy to swallow gel Caps with Vitamin E & Beta carotene as natural preservatives.

300 and 400mg tablets are Vitaline/Integrative Therapeutics chewable wafers, the exact formulas used in the NIH Parkinson’s trials.

Product # 134 Wellness Club CoQ10 (60 softgel Caps 50 mg) 35.95

Product # 135 Wellness Club (60 softgel Caps 100 mg) 62.95

Vitaline CoQ10

Vitaline brand CoQ10 is THE CoQ10 that has been the subject of NIH studies and a recent trial showing its potential value in Parkinson’s patients.

Co10 has been shown to be potentially helpful for:

neurological health
cardiovascular health
anti-aging and longevity

NOTE: Vitaline® brand CoQ10 is available under several different labels.

Vitaline CoQ10 Vitaline Co-Enzyme Q10 Integrative Therapeutics
is the “Doctors Only” label Enzymatic Therapy
is the “Health Food Store” label Vitaline under the “Vitaline Formulas” Label is the same product

THESE ARE ALL THE EXACT SAME PRODUCT That Is Used In The NIH Studies
All are made by Vitaline and given different labels.

Product # N313 Vitaline (60 chewable wafers 300 mg With Vitamin E) 97.00

Product # N334 Vitaline (60 chewable wafers 300 mg WITHOUT Vit. E) 97.00

Product # N314 Vitaline (90 chewable wafers 400 mg With Vitamin E) 197.00

Product # N335 Vitaline (90 chewable wafers 400 mg WITHOUT Vit. E) 197.00

Vitaline, Vitamin E, and Vitamin E safety:

Some people (including some doctors) have a mistaken fear of Vitamin E, believing that “too much is dangerous.”

We have been unable to find any evidence in medical or scientific literature of any danger from taking large doses of Vitamin E. The National Institutes for Health (NIH) a US government authority places the maximum daily intake of Vitamin E at 1500 IU for healthy adults.

High intake of Vitamin E intake does tend to “thin” the blood, affecting coagulation by inhibiting platelet aggregation. People using antigoagulants or who bleed too easily may wish to discuss the use of Vitamin E with theri doctor.It has also been reported that Vitamin E in high doses may block the action of Vitamin K which is known as “the clotting factor.”

According to the label information and the Enzymatic Therapy website:

Vitaline® CoQ10 – 300 mg WITH Vitamin E contains 300 IU Vitamin E per chewable tab.

Vitaline® CoQ10 – 400 mg WITH Vitamin E contains 200 IU Vitamin E per chewable tab.

In order to achieve the daily intake of Vitamin E that you or your health care provider wish you to have you can either use a different tablet strength, either 300 or 400 mg to achieve 1200mg per day or mix your intake between Vitaline WITH and Vitaline WITHOUT Vitamin E to achieve your preferred daily intake of Vitamin E.

Vitaline 400 mg WITHOUT Vitamin E (Cherry-Vanilla flavor) Serving Size: 3 Chewable wafers Amount/Serving %DV Calories 35 Calories from fat 15 Total fat 1.5 gm 2%** Total Carbohydrate 5 gm 2%** Sugars 5 gm * Natural Coenzyme Q10 (trans-CoQ10) (ubiquinone 10) 1.2 gm *

This product does not contain

all colors used are from natural sources
artificial flavoring
corn
dairy products
gluten
ingredients of animal origin
preservatives
salt
soy
sucrose
wheat
yeast

Notes

If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

Manufactured by a Drug GMP audited facility.

**Based on 2000 calorie diet.

Other Ingredients

fructose, dextrose, beet juice color, silicon dioxide, natural flavors, hydrogenated vegetable oil, magnesium stearate, and malic acid.

Vitaline 400 mg WITH Vitamin E (Orange flavor) Serving Size: 3 Chewable wafers Amount/Serving %DV Calories 35 Calories from fat 15 Total fat 1.5 gm 2 %** Total Carbohydrate 5 gm 2 %** Sugars 5 gm * Natural Coenzyme Q10 (trans-CoQ10) (ubiquinone 10) 1.2 gm * Vitamin E (as dl-alpha tocopheryl acetate) 600 IU 2000 %

This product does not contain

all colors used are from natural sources
artificial flavoring
corn
dairy products
gluten
ingredients of animal origin
preservatives
salt
soy
sucrose
wheat
yeast

Notes

If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

Manufactured by a Drug GMP audited facility.

**Based on 2000 calorie diet.

Other Ingredients

dextrose, fructose, silicon dioxide, hydrogenated vegetable oil, natural flavor, citric acid, and magnesium stearate.

Vitaline 300 mg WITH Vitamin E (Maple Nut flavor) Serving Size: 4 Chewable wafers Amount/Serving %DV Calories 35 Calories from fat 10 Total fat 1.5 gm 2 %** Total Carbohydrate 5 gm 2 %** Sugars 5 gm * Natural Coenzyme Q10 (trans-CoQ10) (ubiquinone 10) 1.2 gm * Vitamin E (as dl-alpha tocopheryl acetate) 1200 IU 4000 %

This product does not contain

all colors used are from natural sources
artificial flavoring
corn
dairy products
gluten
ingredients of animal origin
preservatives
salt
soy
sucrose
wheat
yeast

Notes

If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

Manufactured by a Drug GMP audited facility.

**Based on 2000 calorie diet.

Other Ingredients

dextrose, fructose, silicon dioxide, hydrogenated vegetable oil (cottonseed), natural vanilla flavor, magnesium stearate, and natural maple nut flavor.

Vitaline 300 mg WITHOUT Vitamin E (Maple Nutflavor) Serving Size: 4 Chewable wafers Amount/Serving %DV Calories 35 Calories from fat 15 Total fat 1.5 gm 2%** Total Carbohydrate 3 gm 2%** Sugars 3 gm * Natural Coenzyme Q10 (trans-CoQ10) (ubiquinone 10) 1.2 gm *

This product does not contain

all colors used are from natural sources
artificial flavoring
corn
dairy products
gluten
ingredients of animal origin
preservatives
salt
soy
sucrose
wheat
yeast

Notes

If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

Manufactured by a Drug GMP audited facility.

**Based on 2000 calorie diet.

Other Ingredients

dextrose, fructose, cellulose, hydrogenated vegetable oil, partially hydrogenated soybean oil, silicon dioxide, natural vanilla flavor, magnesium stearate, sodium caseinate (milk), and natural maple nut flavor.

References:

CoQ10 – 100mg 60 softgel caps

CoQ10 (ubiquinone)

Super-Energizer and Potent Antioxidant

CoQ10 is a potent antioxidant beneficial for:

Heart Disease (angina, arrhythmia, atherosclerosis, cardiomyopathy, heart failure, congestive heart failure, myocardial infarction (1-18)
High Blood Pressure (1,3,4,14, 53, 55)
Neurological disease (Alzheimer’s, Huntington’s, Parkinson’s) (19-37)
Immune deficiency and AIDS (40-45,52)
Periodontal disease (38-39)
Cancer (40, 44-49)
Chemotherapy side-effects (50-52)
Diabetes (53-56)
Muscular dystrophy (57-58)
fatigue / chronic fatigue / fibromyalgia (59-61)
migraine headache (62-63)
enhancing athletic performance (64-68)
male infertility (69-73)

CoQ10 is produced by the body, but age, nutrient deficiencies, disease and some medications can lower the body’s CoQ10 levels. Cholesterol-lowering drugs (statins) deplete CoQ10. (15,54,74-77)

Studies have shown that the oil-preserved form is up to 3 times better absorbed than other forms. (78-80)

Although many claims are currently made for a “new” form (ubiquinol) being “more absorbable” than ubiquinone, this has never been proven or well-studied. Learn more about this issue here:Ubiquinone (CoQ10) versus Ubiquinol: Which Is Better?

CoQ10 and it’s use in CHF (Congestive Heart Failure):

Suggested dose:

50-100 mg per day for health maintenance and anti-aging / longevity programs.

Each Capsule contains:

100 mg capsules are Wellness Club brand oil-preserved CoQ10 in easy to swallow gel Caps with Vitamin E & Beta carotene as natural preservatives

Natural Support For Unintended Weight Loss

Diet And Lifestyle Recommendations

Primary Support

Additional Support

Dr. Myatt’s Comments (Other Considerations)

How to Calculate Protein & Calorie Requirements

Dr. Myatt’s Final Comment

A 5-Point Program to Stop Smoking for Good

A.) help protect yourself from many of the harmful effects of tobacco use,

B.) stop smoking altogether.

100% Pure Food Grade Tri-Potassium Citrate Powder (Anhydrous Tripotassium Citrate)

References:

A Shot in The Dark?

Why The Flu Vaccine is a Bust

How to Make Yourself Flu-Proof: “Winterize” Your Immune System in Four Easy Steps

1.) Eat an Immune-Boosting Diet. The two major dietary causes of immune suppression are sugar intake and food allergies.

2.) Practice simple home and hygiene techniques.

3.) Strengthen your immune system with supplements.

I Guarantee You Won’t Get The Flu This Winter

Dr. Dana Myatt

Naturopathic Medical Doctor

Naturopathic Medical Doctor

Natural Strategies To Help Avoid Cancer

References

Super Foods

Smoking, Alcohol and Cancer Risk

Drinking Water and Cancer Risk

Exercise and Cancer

Emotional Hygiene and The immune System

Multiple Vitamins and Cancer

Antioxidants (General) and Cancer

Vitamin A and Carotenes

Vitamin C

Selenium

Vitamin D

Omega 3 Essential Fatty Acids

Di-indolymethanes (DIM, IC3)

Turmeric (Curcumin)

Melatonin

Super-Energizer and Potent Antioxidant

Super-Energizer and Potent Antioxidant

Product # 134 Wellness Club CoQ10 (60 softgel Caps 50 mg) 35.95

Product # 135 Wellness Club (60 softgel Caps 100 mg) 62.95

Vitaline CoQ10

Vitaline brand CoQ10 is THE CoQ10 that has been the subject of NIH studies and a recent trial showing its potential value in Parkinson’s patients.

Co10 has been shown to be potentially helpful for:

NOTE: Vitaline® brand CoQ10 is available under several different labels.

Product # N313 Vitaline (60 chewable wafers 300 mg With Vitamin E) 97.00

Product # N334 Vitaline (60 chewable wafers 300 mg WITHOUT Vit. E) 97.00

Product # N314 Vitaline (90 chewable wafers 400 mg With Vitamin E) 197.00

Product # N335 Vitaline (90 chewable wafers 400 mg WITHOUT Vit. E) 197.00

References:

CoQ10 (ubiquinone)

Super-Energizer and Potent Antioxidant

References:

Learning Center

Natural Health Pharmacy

Holistic Health Handbook

What's New?

Varicose Veins

HealthBeat News

HealthBeat News